The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice
Abstract
The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II A β b gene in embryonic stem cells, mice were generated that lack cell surface expression of class II molecules. These MHC class II-deficient mice were depleted of mature CD4 + T cells and were deficient in cell-mediated immune responses. These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4 + T cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bill, J., & Palmer, E. (1989) · Nature · doi:10.1038/341649a0 · Cited by 130
Cited by
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
Tan, J. T., Ernst, B., Kieper, W. C., LeRoy, E., Sprent, J., & Surh, C. D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020066 · Cited by 786
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
Azzam, H. S., Grinberg, A., Lui, K., Shen, H., Shores, E. W., & Love, P. E. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2301 · Cited by 587
Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells
Smiley, S. T., Kaplan, M. H., & Grusby, M. J. (1997) · Science · doi:10.1126/science.275.5302.977 · Cited by 489
Self-citation
Metadata
- Authors
- Grusby, M. J., Johnson, R. S., Papaioannou, V. E., & Glimcher, L. H.
- Venue
- Science
- Published
- 1991-09-20
- Volume
- 253
- Issue
- 5026
- Pages
- 1417-1420
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093143038
- Cited by
- 660
- References
- 1
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice. https://app.cochat.ai/papers/10.1126/science.1910207
- The paper
- Grusby, M. J., Johnson, R. S., Papaioannou, V. E., & Glimcher, L. H. (1991). Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice. Science. https://doi.org/10.1126/science.1910207
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
