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Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation
Abstract
Resonance between beams of x-ray waves and electronic transitions from bound atomic orbitals leads to a phenomenon known as anomalous scattering. This effect can be exploited in x-ray crystallographic studies on biological macromolecules by making diffraction measurements at selected wavelengths associated with a particular resonant transition. In this manner the problem of determining the three-dimensional structure of thousands of atoms is reduced to that of initially solving for a few anomalous scattering centers that can then be used as a reference for developing the entire structure. This method of multiwavelength anomalous diffraction has now been applied in a number of structure determinations. Optimal experiments require appropriate synchrotron instrumentation, careful experimental design, and sophisticated analytical procedures. There are rich opportunities for future applications.
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Metadata
- Authors
- Hendrickson, W. A.
- Venue
- Science
- Published
- 1991-10-04
- Volume
- 254
- Issue
- 5028
- Pages
- 51-58
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969156185
- Cited by
- 1,129
- References
- 0
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- closed
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