The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Stereospecific Effects of Inhalational General Anesthetic Optical Isomers on Nerve Ion Channels
Abstract
Although it is generally agreed that general anesthetics ultimately act on neuronal ion channels, there is considerable controversy over whether this occurs by direct binding to protein or secondarily by nonspecific perturbation of lipids. Very pure optical isomers of the inhalational general anesthetic isoflurane exhibited clear stereoselectivity in their effects on particularly sensitive ion channels in identified molluscan central nervous system neurons. At the human median effect dose (ED 50 ) for general anesthesia, the (+)-isomer was about twofold more effective than the (-)-isomer both in eliciting the anesthetic-activated potassium current I K (An) and in inhibiting a current mediated by neuronal nicotinic acetylcholine receptors. For inhibiting the much less sensitive transient potassium current I A , the (-)-isomer was marginally more potent than the (+)-isomer. Both isomers were equally effective at disrupting lipid bilayers.
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Cites
Do general anaesthetics act by competitive binding to specific receptors?
Franks, N. P., & Lieb, W. R. (1984) · Nature · doi:10.1038/310599a0 · Cited by 572
Self-citationMolecular mechanisms of general anaesthesia
Franks, N. P., & Lieb, W. R. (1982) · Nature · doi:10.1038/300487a0 · Cited by 434
Self-citationPharmacology of Ketamine Isomers in Surgical Patients
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SOLUBILITY COEFFICIENTS FOR INHALED ANAESTHETICS FOR WATER, OIL AND BIOLOGICAL MEDIA
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The Pressure Reversal of General Anesthesia and the Critical Volume Hypothesis
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The Nature of The Site of General Anesthesia
Miller, K. W. (1985) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60555-3 · Cited by 209
Volatile general anaesthetics activate a novel neuronal K+ current
Franks, N. P., & Lieb, W. R. (1988) · Nature · doi:10.1038/333662a0 · Cited by 199
Self-citationWhat is the molecular nature of general anaesthetic target sites?
Franks, N. P., & Lieb, W. R. (1987) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(87)90160-x · Cited by 145
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Cited by
Genetic Regulation of Fruit Development and Ripening
Giovannoni, J. J. (2004) · THE PLANT CELL ONLINE · doi:10.1105/tpc.019158 · Cited by 1,427
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295
Self-citationHalogen atoms in the modern medicinal chemistry: hints for the drug design
Hernandes, M., Cavalcanti, S. M., Moreira, D. R., de Azevedo Junior, W., & Leite, A. C. (2010) · Current Drug Targets · doi:10.2174/138945010790711996 · Cited by 723
Inhalational anesthetics activate two-pore-domain background K+ channels
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Emerging molecular mechanisms of general anesthetic action
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Metadata
- Authors
- Franks, N. P., & Lieb, W. R.
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 427-430
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021818277
- Cited by
- 280
- References
- 15
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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