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Murine Developmental Control Genes
Open accessAbstract
Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. The functions of these genes can be analyzed molecularly in vitro and in vivo with the use of available mouse mutants or transgenic mice. In addition, it has been possible to generate gain- or loss-of-function mutations by random or targeted introduction of transgenes. Models derived from these studies can reveal the successive steps of developmental control on a genetic level.
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Citations
Cited by
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674
Zannini, M., Francis-Lang, H., Plachov, D., & Lauro, R. D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.4230-4241.1992 · Cited by 300
Spatial mechanisms of gene regulation in metazoan embryos
Davidson, E. H. (1991) · Development · doi:10.1242/dev.113.1.1 · Cited by 233
Chapter 9 Hox Genes and Vertebrate Axial Pattern
Wellik, D. M. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88009-5 · Cited by 203
Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation
Shenk, M. A., Bode, H. R., & Steele, R. E. (1993) · Development · doi:10.1242/dev.117.2.657 · Cited by 129
Gray, T. A., Hernandez, L., Carey, A. H., Schaldach, M. A., Smithwick, M. J., Rus, K., Marshall Graves, J. A., Stewart, C. L., & Nicholls, R. D. (2000) · Genomics · doi:10.1006/geno.2000.6199 · Cited by 108
Transcription factors that regulate growth and differentiation of myeloid cells.
Nagamura-Inoue, T., Tamura, T., & Ozato, K. (2001) · International Reviews of Immunology · doi:10.3109/08830180109056724 · Cited by 94
Metadata
- Authors
- Kessel, M., & Gruss, P.
- Venue
- Science
- Published
- 1990-07-27
- Volume
- 249
- Issue
- 4967
- Pages
- 374-379
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985126857
- Cited by
- 585
- References
- 0
- FWCI
- 37.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
