Transcription factors that regulate growth and differentiation of myeloid cells.
Abstract
Recently much progress has been made in our understanding of how myeloid progenitor cells undergo commitment and become mature granulocytes or monocytes/macrophages. Studies of normal and leukemic myeloid cells as well as those of cells derived from mice with targeted disruption showed that a series of transcription factors play a major role in both commitment and maturation of myeloid cells. This is primarily because these transcription factors direct an ordered pattern of gene expression according to a well-defined developmental program. PU.1, an Ets family member, is one of the master transcription factors identified to regulate development of both granulocytes and monocytes/macrophages. Further, C/EBPalpha and C/EBPvarepsilon of the bZip family have important roles in directing granulocytic maturation. A number of additional transcription factors such as AML1, RARalpha, MZF-1, Hox and STAT families of transcription factors, Egr-1 and c-myb etc are shown to play roles in myeloid cell differentiation. Our laboratory has recently obtained evidence that ICSBP, a member of the IRF family, is involved in lineage commitment during myeloid cell differentiation and stimulates maturation of functional macrophages. Future elucidation of pathways and networks through which these transcription factors act in various stages of development would provide a more definitive picture of myeloid cell commitment and maturation.
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In initial descriptions, PU.1 was thought to be largely restricted to myeloid lineages.
“In the initial descriptions of PU.1, it was thought to be largely restricted to myeloid lineages [30].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [30]
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ICSBP Directs Bipotential Myeloid Progenitor Cells to Differentiate into Mature Macrophages
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The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
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- Authors
- Nagamura-Inoue, T., Tamura, T., & Ozato, K.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ozato, Keiko
- Venue
- International Reviews of Immunology
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 20
- Issue
- 1
- Pages
- 83-105
- ISSN
- 0883-0185 (ISSN-L)
- 1563-5244
- OpenAlex
- W2118318352
- Cited by
- 94
- References
- 15
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Reviews of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- transcription factors, myeloid differentiation, myeloid progenitor cells, lineage commitment, granulocyte maturation, PU.1, ETS family, C/EBPα, C/EBPε, bZIP transcription factors, RUNX1, RARα, Hox transcription factors, STAT family, EGR1, MYB, IRF8, macrophage maturation, gene expression regulation
- MeSH terms
- Interferon Regulatory Factor-8, Proto-Oncogene Protein Spi-1, Animals, Cell Differentiation, Cell Division, Cells, Cultured, DNA-Binding Proteins, Multigene Family, Hematopoiesis, Humans, Leukemia, Myeloid, Models, Genetic, Neoplasm Proteins, Proto-Oncogene Proteins, Repressor Proteins, Stem Cells, Transcription Factors, Neoplastic Stem Cells, Oncogene Proteins, Fusion, Trans-Activators, Gene Expression Regulation, Leukemic, Hematopoietic Cell Growth Factors, Zinc Fingers, Leucine Zippers, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Lineage, Myeloid Cells, CCAAT-Enhancer-Binding Protein-alpha, Core Binding Factor Alpha 2 Subunit, Interferon Regulatory Factors, Mice
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