Cited by 129Developmental Biology and Gene RegulationMarine Invertebrate Physiology and EcologyGenomics and Chromatin Dynamics

Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation

Shenk, M. Andrew, Bode, Hans R., Steele, Robert E.·1993·Development

Abstract

Cnox-2 is a HOM/HOX homeobox gene that we have identified in the simple metazoan Hydra vulgaris (Cnidaria: Hydrozoa). Cnox-2 is most closely related to anterior members of the Antennapedia gene complex from Drosophila, with the greatest similarity to Deformed. The Cnox-2 protein is expressed in the epithelial cells of adult hydra polyps in a region-specific pattern along the body axis, at a low level in the head and at a high level in the body column and the foot. The expression pattern of Cnox-2 is consistent with a role in axial pattern formation. Alteration of hydra axial patterning by treatment with diacylglycerol (DAG) results in an increase of head activation down the body column and in a coordinate reduction of Cnox-2 expression in epithelial cells in 'head-like' regions. These results suggest that Cnox-2 expression is negatively regulated by a signaling pathway acting through protein kinase C (PKC), and that the varying levels of expression of Cnox-2 along the body axis have the potential to result in differential gene expression which is important for hydra pattern formation.

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Crossref · 10.1242/dev.117.2.657

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  • Cnidarian Hox-like genes are involved in patterning the oral-aboral axis during regeneration or asexual reproduction of the polyp stage.

    “It has been shown that cnidarian Hox-like genes are involved in the patterning of the oral-aboral axis during regeneration or asexual reproduction of the polyp stage (Schummer et al., 1992;Shenk et al., 1993;Cartwright and Buss, 1999;Galliot 2000).”

    From Conservation of Hox/ParaHox-Related Genes in the Early Development of a Cnidarian (2001) · cites this paper as Shenk et al., 1993

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Authors
Shenk, M. A., Bode, H. R., & Steele, R. E.
Affiliations
University of California, Irvine (US)
Corresponding author
Shenk, M. Andrew
Venue
Development
Published
1993-02-01
Volume
117
Issue
2
Pages
657-667
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2341734344
Cited by
129
References
59
Citations by year
2020: 1 · 2019: 2 · 2017: 3 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
4.12
Type
journal article
Language
en
Open access
closed
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01hd027173-05, 5r01hd024511-04)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 24511, HD-07029, HD 27173)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
Hydra vulgaris, body axis patterning, Deformed, diacylglycerol, protein kinase C signaling, epithelial cells, gene expression regulation
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Diglycerides, Drosophila melanogaster, Genes, Homeobox, Hydra, Microscopy, Fluorescence, Molecular Sequence Data, Morphogenesis, Gene Expression, Sequence Homology, Amino Acid

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