Requirement of Nuclear Prolactin for Interleukin-2—Stimulated Proliferation of T Lymphocytes

Clevenger, Charles V.; Altmann, Scott W.; Prystowsky, Michael B.

doi:10.1126/science.2063207

Requirement of Nuclear Prolactin for Interleukin-2—Stimulated Proliferation of T Lymphocytes

Prolactin (PRL) is necessary for the proliferation of cloned T lymphocytes in response to interleukin-2 (IL-2). Translocation of PRL into the nucleus occurs during IL-2--stimulated mitogenesis. Therefore, the function of intranuclear PRL in T cell proliferation was tested. Eukaryotic expression v…