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Anticonvulsant Action of Excitatory Amino Acid Antagonists
Abstract
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D-aspartic acid. The most potent such compound, 2-amino-7-phosphonoheptanoic acid, was anticonvulsant in both test systems when given either intraperitoneally or intracerebroventricularly. Specific antagonists of excitation that is caused by amino acids provide a new class of anticonvulsant agents.
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Cited by
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes
Boulter, J., Hollmann, M., O'Shea-Greenfield, A., Hartley, M., Deneris, E., Maron, C., & Heinemann, S. (1990) · Science · doi:10.1126/science.2168579 · Cited by 938
II. Excitotoxic models for neurodegenerative disorders
Schwarcz, R., Foster, A. C., French, E. D., Whetsell, W. O., & Köhler, C. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90148-6 · Cited by 466
Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons
Sah, P., Hestrin, S., & Nicoll, R. A. (1989) · Science · doi:10.1126/science.2573153 · Cited by 441
Friedman, L., Pellegrini-Giampietro, D., Sperber, E., Bennett, M., Moshe, S., & Zukin, R. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02697.1994 · Cited by 271
Metadata
- Authors
- Croucher, M. J., Collins, J. F., & Meldrum, B. S.
- Venue
- Science
- Published
- 1982-05-21
- Volume
- 216
- Issue
- 4548
- Pages
- 899-901
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083674587
- Cited by
- 695
- References
- 0
- FWCI
- 30.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
