The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chromosomal Region of the Cystic Fibrosis Gene in Yeast Artificial Chromosomes: A Model for Human Genome Mapping
Abstract
A general strategy for cloning and mapping large regions of human DNA with yeast artificial chromosomes (YAC's) is described. It relies on the use of the polymerase chain reaction to detect DNA landmarks called sequence-tagged sites (STS's) within YAC clones. The method was applied to the region of human chromosome 7 containing the cystic fibrosis (CF) gene. Thirty YAC clones from this region were analyzed, and a contig map that spans more than 1,500,000 base pairs was assembled. Individual YAC's as large as 790 kilobase pairs and containing the entire CF gene were constructed in vivo by meiotic recombination in yeast between pairs of overlapping YAC's.
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Citations
Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
Cited by
Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
Derry, J. M. J., Ochs, H. D., & Francke, U. (1994) · Cell · doi:10.1016/0092-8674(94)90528-2 · Cited by 1,043
An STS-Based Map of the Human Genome
Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S.-H., et al. (1995) · Science · doi:10.1126/science.270.5244.1945 · Cited by 773
Development and applications of a molecular genetic linkage map of the mouse genome
Copeland, N. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90085-5 · Cited by 440
The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region
Foote, S., Vollrath, D., Hilton, A., & Page, D. C. (1992) · Science · doi:10.1126/science.1359640 · Cited by 386
An STS-Based Radiation Hybrid Map of the Human Genome
Stewart, E. A., McKusick, K. B., Aggarwal, A., Bajorek, E., Brady, S., Chu, A., Fang, N., Hadley, D., Harris, M., Hussain, S., et al. (1997) · Genome Research · doi:10.1101/gr.7.5.422 · Cited by 313
Metadata
- Authors
- Green, E. D., & Olson, M. V.
- Venue
- Science
- Published
- 1990-10-05
- Volume
- 250
- Issue
- 4977
- Pages
- 94-98
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067984601
- Cited by
- 236
- References
- 2
- FWCI
- 48.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Green, E. D., & Olson, M. V. (1990). Chromosomal Region of the Cystic Fibrosis Gene in Yeast Artificial Chromosomes: A Model for Human Genome Mapping. Science. https://doi.org/10.1126/science.2218515
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