Cited by 175Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Diet-Induced Hypercholesterolemia in Mice: Prevention by Overexpression of LDL Receptors

Yokode, Masayuki, Hammer, Robert E., Ishibashi, Shun, Brown, Michael S., Goldstein, Joseph L.·1990·Science

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Abstract

The current studies were designed to determine whether chronic overexpression of low density lipoprotein (LDL) receptors in the liver would protect mice from the increase in plasma LDL-cholesterol that is induced by high-fat diets. A line of transgenic mice was studied that express the human LDL receptor gene in the liver under control of the transferrin promoter. When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL. The current data indicate that unregulated overexpression of LDL receptors can protect against diet-induced hypercholesterolemia in mice.

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Authors: Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
ORCID: Ishibashi, Shun
Brown, Michael S.
Goldstein, Joseph L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1990-11-30
Volume: 250
Issue: 4985
Pages: 1273-1275
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2244210
OpenAlex: W2059352674
Cited by: 175
References: 28
Citations by year: 2024: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 3
FWCI: 18.32
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: LDL receptor, hypercholesterolemia, high-fat diet, transgenic mice, liver, LDL cholesterol, bile acids, cholesterol, saturated fat, gene overexpression
MeSH terms: Animals, Cholesterol, Dietary, Dietary Fats, Exons, Humans, Hypercholesterolemia, Introns, Lipoproteins, Lipoproteins, HDL, Cholesterol, LDL, Lipoproteins, VLDL, Liver, Mice, Inbred C57BL, Mice, Transgenic, Nucleic Acid Hybridization, Promoter Regions, Genetic, Receptors, LDL, RNA, Messenger, Transferrin, Gene Expression, Mice, Lipoproteins, IDL

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Diet-Induced Hypercholesterolemia in Mice: Prevention by Overexpression of LDL Receptors

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