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Top-down proteomics

Roberts, David S., Loo, Joseph A., Tsybin, Yury O., Liu, Xiaowen, Wu, Si, Chamot-Rooke, Julia, Agar, Jeffrey N., Paša-Tolić, Ljiljana +2 more·2024·Nature Reviews Methods Primers
DOI 10.1038/s43586-024-00318-2PMC PMC11242913
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  • Top-down proteomics is uniquely positioned to quantify proteoform distributions without enzymatic digestion, thereby linking SDS-PAGE bands/SEC peaks to specific chemical variants and enabling causality rather than correlation in structure-function relationships.

    “Top-down proteomics is uniquely positioned to quantify proteo­ form distributions without enzymatic digestion, thereby linking SDS-PAGE bands/SEC peaks to specific chemical variants and enabling causality rather than correlation in structure-function relationships (Roberts et al., 2024).”

    From Structure-function design of amaranth, buckwheat and quinoa proteins as hydrocolloids for emulsion and gel structuring (2027) · cites this paper as Roberts et al., 2024

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Authors
Roberts, D. S., Loo, J. A., Tsybin, Y. O., Liu, X., Wu, S., Chamot-Rooke, J., Agar, J. N., Paša-Tolić, L., Smith, L. M., & Ge, Y.
ORCID
Venue
Nature Reviews Methods Primers
Publisher
Springer Science and Business Media LLC
Published
2024-06-13
Volume
4
Issue
1
ISSN
2662-8449
DOI
10.1038/s43586-024-00318-2
PMC
PMC11242913
Cited by
154
References
61
Language
en
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