Cited by 574Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismCerebrovascular and Carotid Artery Diseases

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

Ross, Russell, Masuda, Junichi, Raines, Elaine W., Gown, Allen M., Katsuda, Shogo, Sasahara, Masakiyo, Malden, L. Trevor, Masuko, Hideyuki +1 more·1990·Science

Abstract

Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.

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Crossref · 10.1126/science.2343305

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49 of 49 references verified0 citation errors · 0 not checkable

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  • In mice, fibrous cap VSMCs are derived from medial VSMCs that migrated and proliferated in response to cytokines and growth factors such as PDGF from macrophages and activated ECs.

    “In mice, the fibrous cap VSMCs are derived from medial VSMCs 22,138 that have undergone migration and proliferation in response to cytokines and growth factors, such as PDGF, derived from macrophages and activated ECs 23,129,139 .”

    From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [129]

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Authors
Ross, R., Masuda, J., Raines, E. W., Gown, A. M., Katsuda, S., Sasahara, M., Malden, L. T., Masuko, H., & Sato, H.
Affiliations
  • University of Washington (US)
  • National Cerebral and Cardiovascular Center (JP)
  • Mochida Pharmaceutical (Japan) (JP)
Venue
Science
Published
1990-05-25
Volume
248
Issue
4958
Pages
1009-1012
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1974790290
Cited by
574
References
49
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 6
FWCI
25.50
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl029873-05)
  • National Heart, Lung, and Blood Institute (HL-18645, HL29873, P01HL018645)
  • National Center for Research Resources (RR00166, P51RR000166)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords
platelet-derived growth factor B-chain, macrophages, atherosclerosis, atherogenesis, smooth muscle cell proliferation, intimal thickening, lipid-laden macrophages, growth factors, chemotaxis, non-human primates
MeSH terms
Animals, Antibodies, Monoclonal, Arteriosclerosis, Diet, Atherogenic, Humans, Immunohistochemistry, Macaca nemestrina, Macrophages, Monocytes, Platelet-Derived Growth Factor, RNA, Messenger, Blotting, Northern

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