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Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis
Abstract
Several clinical features are consistent with nervous system involvement in the pathogenesis of rheumatoid arthritis. The neuropeptide substance P is one possible mediator of this interaction, since it can be released into joint tissues from primary sensory nerve fibers. The potential effects of the peptide on rheumatoid synoviocytes were examined. The results show that substance P stimulates prostaglandin E 2 and collagenase release from synoviocytes. Furthermore, synoviocyte proliferation was increased in the presence of the neuropeptide. Similar effects were observed with a truncated form of substance P. Synoviocytes were sensitive to very small doses of the neuropeptide (10 -9 M ), and its effects were inhibited by a specific antagonist. Thus, the specific stimulation of synoviocytes by the neuropeptide substance P represents a pathway by which the nervous system might be directly involved in the pathogenesis of rheumatoid arthritis.
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Citations
Cited by
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Sellam, J., & Berenbaum, F. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.159 · Cited by 1,500
Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes
Lotz, M., Vaughan, J. H., & Carson, D. A. (1988) · Science · doi:10.1126/science.2457950 · Cited by 915
Self-citationNeuropeptide substance P and the immune response
Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2293-z · Cited by 493
Hong, H. S., Lee, J., Lee, E., Kwon, Y. S., Lee, E., Ahn, W., Jiang, M. H., Kim, J. C., & Son, Y. (2009) · Nature Medicine · doi:10.1038/nm.1909 · Cited by 349
Miller, L. E., Jüsten, H., Schcölmerich, J., & Straub, R. H. (2000) · The FASEB Journal · doi:10.1096/fj.99-1082com · Cited by 294
Metadata
- Authors
- Lotz, M., Carson, D. A., & Vaughan, J. H.
- Venue
- Science
- Published
- 1987-02-20
- Volume
- 235
- Issue
- 4791
- Pages
- 893-895
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035808396
- Cited by
- 444
- References
- 0
- FWCI
- 21.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lotz, M., Carson, D. A., & Vaughan, J. H. (1987). Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis. Science. https://doi.org/10.1126/science.2433770
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