Cited by 493Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsVagus Nerve Stimulation Research

Neuropeptide substance P and the immune response

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Mashaghi, Alireza, Marmalidou, Anna, Tehrani, Mohsen, Grace, Peter M., Pothoulakis, Charalabos, Dana, Reza·2016·Cellular and Molecular Life Sciences

Abstract

Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation. Animal models have provided insights into the biology of this peptide and offered compelling evidence for the importance of substance P in cell-to-cell communication by either paracrine or endocrine signaling. Substance P mediates interactions between neurons and immune cells, with nerve-derived substance P modulating immune cell proliferation rates and cytokine production. Intriguingly, some immune cells have also been found to secrete substance P, which hints at an integral role of substance P in the immune response. These communications play important functional roles in immunity including mobilization, proliferation and modulation of the activity of immune cells. This review summarizes current knowledge of substance P and its receptors, as well as its physiological and pathological roles. We focus on recent developments in the immunobiology of substance P and discuss the clinical implications of its ability to modulate the immune response.

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Authors
Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R.
Affiliations
  • Massachusetts Eye and Ear Infirmary (US)
  • University of Colorado Boulder (US)
  • University of California, Los Angeles (US)
Corresponding author
Dana, Reza
Venue
Cellular and Molecular Life Sciences
Published
2016-06-17
Volume
73
Issue
22
Pages
4249-4264
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2442224165
Cited by
493
References
258
Citations by year
2026: 61 · 2025: 56 · 2024: 53 · 2023: 73 · 2022: 64 · 2021: 65 · 2020: 53 · 2019: 29 · 2018: 20 · 2017: 16 · 2016: 1
FWCI
2.41
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
Foundation for the National Institutes of Health (R01 DK047343, EY020889, EY012963)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
substance P, neuropeptides, immune response, neuroimmune interactions, neurokinin-1 receptor, cytokine production, immune cell proliferation, inflammation, nociception, paracrine signaling, hormone signaling, immune cell mobilization
MeSH terms
Amino Acid Sequence, Animals, Disease, Humans, Immunity, Substance P, Signal Transduction, Immunomodulation

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