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Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila
Abstract
Potassium currents are crucial for the repolarization of electrically excitable membranes, a role that makes potassium channels a target for physiological modifications that alter synaptic efficacy. The Shaker locus of Drosophila is thought to encode a K + channel. The sequence of two complementary DNA clones from the Shaker locus is reported here. The sequence predicts an integral membrane protein of 70,200 daltons containing seven potential membrane-spanning sequences. In addition, the predicted protein is homologous to the vertebrate sodium channel in a region previously proposed to be involved in the voltage-dependent activation of the Na + channel. These results support the hypothesis that Shaker encodes a structural component of a voltage-dependent K + channel and suggest a conserved mechanism for voltage activation.
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Cited by
Phylogenetic Relationships within Cation Transporter Families of Arabidopsis
Mäser, P., Thomine, S., Schroeder, J. I., Ward, J. M., Hirschi, K., Sze, H., Talke, I. N., Amtmann, A., Maathuis, F. J. M., Sanders, D., et al. (2001) · Plant Physiology · doi:10.1104/pp.126.4.1646 · Cited by 1,257
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs
Liman, E. R., Tytgat, J., & Hess, P. (1992) · Neuron · doi:10.1016/0896-6273(92)90239-a · Cited by 1,084
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N., & Jan, L. Y. (1987) · Science · doi:10.1126/science.2441470 · Cited by 721
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Metadata
- Authors
- Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N., & Jan, L. Y.
- Venue
- Science
- Published
- 1987-08-14
- Volume
- 237
- Issue
- 4816
- Pages
- 770-775
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038321772
- Cited by
- 652
- References
- 0
- FWCI
- 17.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N., & Jan, L. Y. (1987). Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila. Science. https://doi.org/10.1126/science.2441471
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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