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Sequence and Expression of mRNAs Encoding the α 1 and α 2 Subunits of a DHP-Sensitive Calcium Channel
Abstract
Complementary DNAs were isolated and used to deduce the primary structures of the α 1 and α 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from rabbit skeletal muscle. The α 1 subunit, which contains putative binding sites for calcium antagonists, is a hydrophobic protein with a sequence that is consistent with multiple transmembrane domains and shows structural and sequence homology with other voltage-dependent ion channels. In contrast, the α 2 subunit is a hydrophilic protein without homology to other known protein sequences. Nucleic acid hybridization studies suggest that the α 1 and α 2 subunit mRNAs are expressed differentially in a tissue-specific manner and that there is a family of genes encoding additional calcium channel subtypes.
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Citations
Cited by
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Voltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Modulation of CaV2.1 Channels by the Neuronal Calcium-Binding Protein Visinin-Like Protein-2
Lautermilch, N. J., Few, A. P., Scheuer, T., & Catterall, W. A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0447-05.2005 · Cited by 89
Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
Alves, V. S., Alves-Silva, H. S., Orts, D. J. B., Ribeiro-Silva, L., Arcisio-Miranda, M., & Oliveira, F. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.041 · Cited by 34
Metadata
- Authors
- Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., Campbell, K. P., McKenna, E., Koch, W. J., Hui, A., Schwartz, A., & Harpold, M. M.
- Venue
- Science
- Published
- 1988-09-23
- Volume
- 241
- Issue
- 4873
- Pages
- 1661-1664
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012093804
- Cited by
- 571
- References
- 0
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., Campbell, K. P., McKenna, E., Koch, W. J., Hui, A., Schwartz, A., & Harpold, M. M. (1988). Sequence and Expression of mRNAs Encoding the α 1 and α 2 Subunits of a DHP-Sensitive Calcium Channel. Science. https://doi.org/10.1126/science.2458626
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