The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells
Abstract
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Volatile general anaesthetics activate a novel neuronal K+ current
Franks, N. P., & Lieb, W. R. (1988) · Nature · doi:10.1038/333662a0 · Cited by 199
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Tallima, H., & El Ridi, R. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2017.11.004 · Cited by 671
Effect of fatty acids on energy coupling processes in mitochondria
Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363
pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.
Kamp, F., & Hamilton, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11367 · Cited by 299
Effects of membrane lipids on ion channel structure and function
Tillman, T. S., & Cascio, M. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:38:2:161 · Cited by 265
Gamma linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial
Zurier, R. B., Rossetti, R. G., Jacobson, E. W., Demarco, D. M., Liu, N. Y., Temming, J. E., White, B. M., & Laposata, M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391106 · Cited by 217
Metadata
- Authors
- Ordway, R. W., Walsh, J. V., & Singer, J. J.
- Venue
- Science
- Published
- 1989-06-09
- Volume
- 244
- Issue
- 4909
- Pages
- 1176-1179
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999557771
- Cited by
- 350
- References
- 2
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ordway, R. W., Walsh, J. V., & Singer, J. J. (1989). Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells. Science. https://doi.org/10.1126/science.2471269
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
