Cited by 2,834Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

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The Crisis in Antibiotic Resistance

Neu, Harold C.·1992·Science

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Abstract

The synthesis of large numbers of antibiotics over the past three decades has caused complacency about the threat of bacterial resistance. Bacteria have become resistant to antimicrobial agents as a result of chromosomal changes or the exchange of the exchange of genetic material via plasmids and transposons. Streptococcus pneumoniae, Streptococcus pyogenes, and staphylococci, organisms that cause respiratory and cutaneous infections, and members of the Enterobacteriaceae and Pseudomonas families, organisms that cause diarrhea, urinary infection, and sepsis, are now resistant to virtually all of the older antibiotics. The extensive use of antibiotics in the community and hospitals has fueled this crisis. Mechanisms such as antibiotic control programs, better hygiene, and synthesis of agents with improved antimicrobial activity need to be adopted in order to limit bacterial resistance.

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Crossref · 10.1126/science.257.5073.1064

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Prevalence of Antibiotic Resistance among Escherichia coli from Different Sources in Malaysia
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“…bacteria is of major concern and antibiotic use is suggested to be a major risk factor for the development of antibiotic resistance (Neu, 1992; Witte, 1998), along with other factors like the use of antibiotics in animals and humans for control of bacterial infections and may be…”
Background
Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults
Chastre, J. E., Wolff, M., Fagon, J.-Y., Chevret, S., Thomas, F., Wermert, D., Clementi, E., Gonzalez‐Bermejo, J., Jusserand, D., Asfar, P., et al. (2007) · Cited by 39
Multiresidue determination of quinolone antibiotics using liquid chromatography coupled to atmospheric‐pressure chemical ionization mass spectrometry and tandem mass spectrometry
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Child Care Center Staff Contribute to Physician Visits and Pressure for Antibiotic Prescription
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Dihydropteroate Synthase fromStreptococcus pneumoniae:Characterization of Substrate Binding Order and Sulfonamide Inhibition
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Protective Immunity of Microsphere-Based Mucosal Vaccines against Lethal Intranasal Challenge withStreptococcus pneumoniae
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“pneumoniae has had a great impact on the practice of outpatient medicine (24).”
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Peptide deformylase: a target for novel antibiotics?
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“The widespread use and misuse of antibiotics has forced bacteria to evolve and develop resistance to just about every antibiotic that has been used clinically [1].”
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Epistatic effects of promoter and repressor functions of the Tn 10 tetracycline‐resistance operon on the fitness of Escherichia coli
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Rapid resistance to pesticide control is predicted to evolve in an invasive fish
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“(2) and nm and na are constants that control the strength of density dependence.”
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Corneal collagen cross‐linking for infectious keratitis: an update of clinical studies
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“Chromosomal mutation, expression of latent chromosomal genes by induction and exchange of genetic material via transformation are the major mechanisms of antibiotic resistance development (Neu 1992; Bennett et al. 1998).”
Background
Structural Origins of Oxacillinase Specificity in Class D β-Lactamases
June, C. M., Vallier, B. C., Bonomo, R. A., Leonard, D. A., & Powers, R. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01483-13 · Cited by 38
“However, their clinical use is threatened by the overuse and misuse of these drugs (1).”
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Identification of three novel Phyllomedusa sauvagei dermaseptins (sVI–sVIII) by cloning from a skin secretion-derived cDNA library
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“Diarrheal outpatients (n = 30) 26 (87) 4 (13) 1 (3) 7 (23) 1 (3) 10 (33) 0 (0)”
Microbial metabolite deoxycholic acid shapes microbiota against Campylobacter jejuni chicken colonization
Alrubaye, B., Abraha, M., Almansour, A. M., Bansal, M., Wang, H., Kwon, Y. M., Huang, Y., Hargis, B. M., & Sun, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214705 · Cited by 37
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Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates
Dera, A. A., Ahmad, I. S., Rajagopalan, P., Shahrani, M. M. A., Saif, A., Alshahrani, M. Y., Alraey, Y., Alamri, A. M., Alasmari, S., Makkawi, M., et al. (2021) · Saudi Medical Journal · doi:10.15537/smj.2021.2.25706 · Cited by 38
Identification of Anti-Wood Rot Compounds in Teak ( Tectona grandis L.f.) Sawdust Extract
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“[ 33 , 34 , 35 , 36 ]”
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Emergence and Persistence of Macrolide Resistance in Oropharyngeal Flora and Elimination of Nasal Carriage of Staphylococcus aureus after Therapy with Slow-Release Clarithromycin: a Randomized, Double-Blind, Placebo-Controlled Study
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Primary identification of Aureobacterium spp. isolated from clinical specimens as "Corynebacterium aquaticum"
Funke, G., von Graevenitz, A., & Weiss, N. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.11.2686-2691.1994 · Cited by 38
PLASMID BORNE ANTIBIOTIC RESISTANCE FACTORS AMONG INDIGENOUS KLEBSIELLA
Rasool, S. A., Ahmad, A., Khan, S., & Wahab, A. (2003) · Cited by 38
A Chemical Approach to Generate Molecular Diversity Based on the Scaffold of Cyclic Decapeptide Antibiotic Tyrocidine A
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Identification of Harman as the Antibiotic Compound Produced by a Tunicate-Associated Bacterium
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PATHOGENS RESISTANT TO ANTIMICROBIAL AGENTS
Fraimow, H. S., & Abrutyn, E. (1995) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30683-8 · Cited by 37
Nanomedicine for drug resistant pathogens and COVID-19 using mushroom nanocomposite inspired with bacteriocin – A review
Srinivash, M., Krishnamoorthi, R., Mahalingam, P. U., Malaikozhundan, B., Bharathakumar, S., Gurushankar, K., Dhanapal, K., Samy, K. K., & Perumal, A. B. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.110682 · Cited by 37
“One of the fundamental principle of bacterial resistance is the change of the antibiotics target [169].”
Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: Identification of novel brevinins from three species of Chinese frogs
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Toward hemocompatible self-assembling antimicrobial nanofibers: understanding the synergistic effect of supramolecular structure and PEGylation on hemocompatibility
Xu, D., Ran, Q., Xiang, Y., Jiang, L., Smith, B. M., Bou‐Abdallah, F., Lund, R., Li, Z., & Dong, H. (2016) · RSC Advances · doi:10.1039/c5ra24553b · Cited by 37
Specificity in the Susceptibilities of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Clinical Isolates to Six Metal Antimicrobials
Gugala, N. A., Vu, D., Parkins, M. D., & Turner, R. J. (2019) · Antibiotics · doi:10.3390/antibiotics8020051 · Cited by 38
“In our modern era, the rising incidence of antibiotic resistance is a familiar concern that continues to provide challenges in infection control and disease prevention [1,2].”
Background
Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital
León, I. M., Lawhon, S. D., Norman, K. N., Threadgill, D. W., Ohta, N., Vinasco, J., & Scott, H. M. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02829-17 · Cited by 37
Synthesis, antibacterial activity and docking studies of substituted quinolone thiosemicarbazones
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“Due to the emergence of antibacterial resistance, alternatives to commonly used antibiotics are needed.([32,33]) Thus, a small library of quinolone thiosemicarbazones were synthesized and tested for antibacterial activity in order to identify hit compounds to be used as leads in the fight against antibacterial resista…”
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Determination and occurrence of sulfonamide transformation products in surface waters
Cui, H., Chang, H., Zheng, H., & Wan, Y. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146562 · Cited by 37
Effects of selected herbs and essential oils on performance, egg quality and some metabolic activities in laying hens – a review
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Antifouling and Antibacterial Surfaces Grafted with Sulfur-Containing Copolymers
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Background

Authors: Neu, H. C.
Affiliations: Columbia University (US)
Corresponding author: Neu, Harold C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-08-21
Volume: 257
Issue: 5073
Pages: 1064-1073
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.257.5073.1064
OpenAlex: W1980595924
Cited by: 2,834
References: 109
Citations by year: 2026: 23 · 2025: 48 · 2024: 57 · 2023: 71 · 2022: 91 · 2021: 93 · 2020: 123 · 2019: 100 · 2018: 122 · 2017: 123 · 2016: 105 · 2015: 87 · 2014: 95 · 2013: 109 · 2012: 99
FWCI: 46.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: antibiotic resistance, bacterial resistance, plasmids, transposable elements, horizontal gene transfer, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus, Enterobacteriaceae, Pseudomonas, antibiotic overuse, hygiene, novel antimicrobial agents
MeSH terms: Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Microbial, Enterobacteriaceae, Haemophilus influenzae, Humans, Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus

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The Crisis in Antibiotic Resistance

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