Cited by 2,834Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

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The Crisis in Antibiotic Resistance

Neu, Harold C.·1992·Science

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Abstract

The synthesis of large numbers of antibiotics over the past three decades has caused complacency about the threat of bacterial resistance. Bacteria have become resistant to antimicrobial agents as a result of chromosomal changes or the exchange of the exchange of genetic material via plasmids and transposons. Streptococcus pneumoniae, Streptococcus pyogenes, and staphylococci, organisms that cause respiratory and cutaneous infections, and members of the Enterobacteriaceae and Pseudomonas families, organisms that cause diarrhea, urinary infection, and sepsis, are now resistant to virtually all of the older antibiotics. The extensive use of antibiotics in the community and hospitals has fueled this crisis. Mechanisms such as antibiotic control programs, better hygiene, and synthesis of agents with improved antimicrobial activity need to be adopted in order to limit bacterial resistance.

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The life and times of the Enterococcus
Murray, B. E. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.46 · Cited by 1,887
Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium
Leclercq, R., Derlot, E., Duval, J., & Courvalin, P. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807213190307 · Cited by 1,411
Enterobacter Bacteremia: Clinical Features and Emergence of Antibiotic Resistance during Therapy
Chow, J. W., Fine, M. J., Shlaes, D. M., Quinn, J. P., Hooper, D. C., Johnson, M. P., Ramphal, R., Wagener, M. M., Miyashiro, D. K., & Yu, V. L. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-8-585 · Cited by 887
Pneumococcal resistance to antibiotics
Klugman, K. P. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.2.171 · Cited by 804
Extended-spectrum beta-lactamases
Philippon, A., Labia, R., & Jacoby, G. A. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.8.1131 · Cited by 776
More extended-spectrum beta-lactamases
Jacoby, G. A., & Medeiros, A. A. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.9.1697 · Cited by 704
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA
Bugg, T. D. H., Wright, G. D., Dutka‐Malen, S., Arthur, M., Courvalin, P. M., & Walsh, C. T. (1991) · Biochemistry · doi:10.1021/bi00107a007 · Cited by 642
Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification
Leclercq, R., & Courvalin, P. M. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.7.1267 · Cited by 629
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
McMurry, L. M., Petrucci, R., & Levy, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3974 · Cited by 606
Antimicrobial resistance of Staphylococcus aureus: genetic basis
Lyon, B. R., & Skurray, R. A. (1987) · Microbiological Reviews · doi:10.1128/mr.51.1.88-134.1987 · Cited by 593

Show all 109 references

Research works printed but not linked: 30

AMERICAN JOURNAL OF MEDICINE 91 3B (1991).
APPELBAUM, P. C., EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 6: 367 (1987).
BANERJEE, S.N., SECULAR TRENDS IN NOSOCOMIAL PRIMARY BLOOD-STREAM INFECTIONS IN THE UNITED-STATES, 1980-1989, AMERICAN JOURNAL OF MEDICINE 91: S86 (1991).
BOYCE, J. M., JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 249: 2803 (1983). · DOI
Bryan, L. E., Antimicrobial Drug Resistance 241 (1984).
BUOHO, A. Y., JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 22 B: 41 (1988).
BUSH, K, ANTIMICROB AGENTS CH 33: 339 (1989).
COOKSON, B. D., JOURNAL OF APPLIED BACTERIOLOGY 69: 55S (1990).
DEGUCHI, K, JAPANESE JOURNAL OF ANTIBIOTICS 42: 2133 (1990).
Fisher, M., New Antibacterial Strategies 177 (1990).
Higgins, C. F., New Antibacterial Strategies 193 (1990).
KHARDORI, N, REVIEWS OF INFECTIOUS DISEASES 12: 996 (1990).
LUJAN, R, REVISTA ESPANOLA DE QUIMIOTERAPIA 3: 323 (1990).
McMurry, L., Proceedings of the National Academy of Sciences of the United States of America 77: 3974 (1980).
MILATOVIC, D, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 6: 234 (1987).
Mitsuhashi, S., The Aminoglycosides 97 (1982).
MOELLERING, R, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 28: 1 (1991).
MUDDER, R.R., ARCH INTERN MED 147: 1672 (1987). · DOI
NEU, H. C., AMERICAN JOURNAL OF MEDICINE 76: 11 (1984).
NEU, H.C., AMERICAN JOURNAL OF MEDICINE 7 5A: 2 (1985).
Neu, H. C., Human Pharmacology 613 (1991).
Normark, S., New Antibacterial Strategies 161 (1990).
PHILLIPS, I, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 27: 40 (1991).
SCHABERG, D. R., AMERICAN JOURNAL OF MEDICINE 91 3B: 725 (1991).
SKURRAY, R. A., JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 21 C: 19 (1988).
SLOCOMBE, B,JOURNAL OF HOSPITAL INFECTION 19: 19 (1991).
SMITH, A, INFECTIOUS DISEASE CLINICS OF NORTH AMERICA 5: 177 (1992).
TALLY, F. P., JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 22 A: 63 (1989).
TENOVER, F. C., AMERICAN JOURNAL OF MEDICINE 91: S76 (1991).
UTTLEY, AHC, VANCOMYCIN-RESISTANT ENTEROCOCCI, LANCET 1: 57 (1988).

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Bengsch, S., Boos, K., Nagel, D., Seidel, D., & Inthorn, D. (2005) · PubMed · Cited by 65
Factors associated with antibiotic use for acute bronchitis
Gonzales, R., Barrett, P. H., Crane, L. A., & Steiner, J. F. (1998) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1998.00165.x · Cited by 65
Infection control and prevention strategies in the ICU
Widmer, A. F. (1994) · Intensive Care Medicine · doi:10.1007/bf01713976 · Cited by 65
“Towards the year 2000, clinicians will face the challenge of infections against which none of the current antimicrobial agents are effective; most clinicians are not yet aware of this impending crisis [7].”
Background
Safety Assessment of Nanomaterials for Antimicrobial Applications
Ali, A. S., Ovais, M., Cui, X., Rui, Y., & Chen, C. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00519 · Cited by 65
Photo‐Enhanced Antimicrobial Activity of Polymers Containing an Embedded Photosensitiser
Judzewitsch, P. R., Corrigan, N. A., Wong, E. H. H., & Boyer, C. A. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202110672 · Cited by 64
Nanomaterials‐Enabled Physicochemical Antibacterial Therapeutics: Toward the Antibiotic‐Free Disinfections
Xing, Z., Guo, J., Wu, Z., He, C., Wang, L., Bai, M., Liu, X., Zhu, B., Guan, Q., & Cheng, C. (2023) · Small · doi:10.1002/smll.202303594 · Cited by 64
Mupirocin: biosynthesis, special features and applications of an antibiotic from a Gram-negative bacterium
Gurney, R., & Thomas, C. M. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3128-3 · Cited by 64
“MRSA colonising the skin and nose can easily be transferred to other areas of the body or wounds, thus causing particular concern during surgical procedures and when cuts or burns are open (Neu 1992).”
Background
Nisin F-loaded brushite bone cement prevented the growth of Staphylococcus aureus in vivo
Staden, A. D. P. V., Brand, A. M., & Dicks, L. M. T. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05241.x · Cited by 66
“As with any antimicrobial, the risk of the target organism acquiring resistance is still a possibility (Neu 1992; Crandall and Montville 1998; Walsh 2003; Kramer et al. 2004).”
Background
Exploring the Antibacterial and Hemolytic Activity of Shorter‐ and Longer‐Chain β‐, α,β‐, and γ‐Peptides, and of β‐Peptides from β2‐3‐Aza‐ and β3‐2‐Methylidene‐amino Acids Bearing Proteinogenic Side Chains – A Survey
Arvidsson, P. I., Ryder, N. S., Weiss, H., Hook, D. F., Escalante, J., & Seebàch, D. (2005) · Chemistry & Biodiversity · doi:10.1002/cbdv.200590020 · Cited by 64
Characterization of Staphylococcus xylosus and Staphylococcus carnosus isolated from Slovak meat products
Simonová, M. P., Strompfová, V., Marciňáková, M., Lauková, A., Vesterlund, S., Latorre‐Moratalla, M. L., Bover‐Cid, S., & Vidal‐Carou, M. C. (2006) · Meat Science · doi:10.1016/j.meatsci.2006.02.004 · Cited by 64
“CNS arises mainly from human and animal environments and several studies have reported the presence of antibiotic resistant genes in CNS isolated from food (Neu, 1992; Perreten, Giamp, Schuler-Schmid, & Teuber, 1998).”
Background
The current epidemiology and clinical decisions surrounding acute respiratory infections
Zaas, A. K., Garner, B. H., Tsalik, E. L., Burke, T. W., Woods, C. W., & Ginsburg, G. S. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.08.001 · Cited by 63
Antibiotic-Resistant Organisms Cultured from Atlantic Bottlenose Dolphins (Tursiops truncatus) Inhabiting Estuarine Waters of Charleston, SC and Indian River Lagoon, FL
Schaefer, A. M., Goldstein, J. D., Reif, J. S., Fair, P. A., & Bossart, G. D. (2009) · EcoHealth · doi:10.1007/s10393-009-0221-5 · Cited by 64
Combretum woodii (Combretaceae) leaf extracts have high activity against Gram-negative and Gram-positive bacteria
Eloff, J. N., Famakin, J. O., & Katerere, D. R. (2005) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2005.000-3231 · Cited by 64
“Fax: +27-12-529-8525. members of the Enterobacteriaceae, causing diarrhoea, urinary tract infections, and sepsis, are now resistant to virtually all of the older antibiotics (Harold, 1992).”
Background
Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs
Sun, C., Hunt, D. K., Clark, R. B., Lofland, D., O’Brien, W. J., Plamondon, L., & Xiao, X.-Y. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm1015395 · Cited by 64
Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps
Tintino, S. R., Oliveira–Tintino, C. D. D. M., Campina, F. F., Costa, M. D. S., de Menezes, I. R. A., de Matos, Y. M. L. S., Júnior, J. T. C., Pereira, P. S., Siqueira-Júnior, J. P., Leal‐Balbino, T. C., et al. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.08.004 · Cited by 64
Synergistic mechanism of Ag+–Zn2+ in anti-bacterial activity against Enterococcus faecalis and its application against dentin infection
Fan, W., Sun, Q., Li, Y., Tay, F. R., & Fan, B. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0336-3 · Cited by 64
Antibacterial Polymers – A Mini Review
Arora, A., & Mishra, A. (2018) · Materials Today Proceedings · doi:10.1016/j.matpr.2018.04.124 · Cited by 65
Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)
Surwade, P., Ghildyal, C., Weikel, C. A., Luxton, T. P., Peloquin, D. M., Fan, X., & Shah, V. (2018) · The Journal of Antibiotics · doi:10.1038/s41429-018-0111-6 · Cited by 64
Die Bekämpfung multiresistenter Bakterien: aktuelle Strategien zur Entdeckung neuer Antibiotika
O’Connell, K. M. G., Hodgkinson, J. T., Sore, H. F., Welch, M., Salmond, G. P. C., & Spring, D. R. (2013) · Angewandte Chemie · doi:10.1002/ange.201209979 · Cited by 63
Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights
He, F., Wu, X., Zhang, Q., Li, Y., Ye, Y., Li, P., Chen, S., Peng, Y., Hardeland, R., & Xia, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683879 · Cited by 68
Green, unexpected synthesis of bis-coumarin derivatives as potent anti-bacterial and anti-inflammatory agents
Chougala, B. M., Samundeeswari, S., Holiyachi, M., Naik, N. S., Shastri, L. A., Dodamani, S., Jalalpure, S. S., Dixit, S. R., Joshi, S. D., & Sunagar, V. A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.072 · Cited by 63
Antibiotic resistance in bacterial urinary tract infections, 1991 to 1997.
Dyer, I. E., Sankary, T. M., & Dawson, J. A. (1998) · Europe PMC (PubMed Central) · Cited by 63
Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance
Cho, M., Gayen, A., Banigan, J. R., Leninger, M., & Traaseth, N. J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503145x · Cited by 62
Vaccination to reduce antimicrobial resistance
Ginsburg, A. S., & Klugman, K. P. (2017) · The Lancet Global Health · doi:10.1016/s2214-109x(17)30364-9 · Cited by 62
Three-dimensional label-free observation of individual bacteria upon antibiotic treatment using optical diffraction tomography
Oh, J., Ryu, J. S., Lee, M., Jung, J., Han, S.-Y., Chung, H. J., & Park, Y. (2020) · Biomedical Optics Express · doi:10.1364/boe.377740 · Cited by 62
Design of a Novel Mammalian Screening System for the Detection of Bioavailable, Non-cytotoxic Streptogramin Antibiotics.
AUBEL, D., Morris, R. P., LENNON, B., Rimann, M., Kaufmann, H., Folcher, M., Bailey, J. E., Thompson, C. J., & Fussenegger, M. (2001) · The Journal of Antibiotics · doi:10.7164/antibiotics.54.44 · Cited by 62
Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics
Llewellyn, N. M., & Spencer, J. B. (2006) · Natural Product Reports · doi:10.1039/b604709m · Cited by 62
Antimicrobial Susceptibility of Udder Pathogens Isolated from Dairy Herds in the West Littoral Region of Uruguay
Gianneechini, R. E., Concha, C., & Franklin, A. (2002) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-43-31 · Cited by 62
“The antimicrobial resistance is the result of mutations or exchange of genetic material such as plasmids and transposons (Neu 1992).”
Background
Screening for Novel Antimicrobials from Encoded Combinatorial Libraries by Using a Two-Dimensional Agar Format
Silen, J. L., Lu, A. T., Solas, D. W., Gore, M. A., Maclean, D., Shah, N. H., Coffin, J. M., Bhinderwala, N. S., Wang, Y., Tsutsui, K., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.6.1447 · Cited by 62
“Rapid emergence of drug-resistant bacterial pathogens has led to a demand for novel antimicrobial compounds (4, 5, 18, 22).”
Background
Randomized, double-blind, comparative study of grepafloxacin and amoxycillin in the treatment of patients with community-acquired pneumonia
O’Doherty, B., Dutchman, D. A., Pettit, R., & Maroli, A. N. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.suppl_1.73 · Cited by 62
“influenzae is implicated as a causative pathogen in around 10% of cases of CAP and some strains have now acquired resistance to ampicillin, primarily caused by -lactamase production.(9) Furthermore, 80–90% of clinical M.”
Background
New antibiotic discovery, novel screens, novel targets and impact of microbial genomics
Allsop, A. E. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80085-4 · Cited by 62
Sulfamethoxazole persistence in a river water ecosystem and its effects on the natural microbial community and Lemna minor plant
Grenni, P., Patrolecco, L., Rauseo, J., Spataro, F., Lenola, M. D., Aimola, G., Zacchini, M., Pietrini, F., Baccio, D. D., Stanton, I. C., et al. (2019) · Microchemical Journal · doi:10.1016/j.microc.2019.103999 · Cited by 61
Indole-based novel small molecules for the modulation of bacterial signalling pathways
Biswas, N. N., Kutty, S. K., Barraud, N., Iskander, G. M., Griffith, R., Rice, S. A., Willcox, M. D. P., Black, D. S., & Kumar, N. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob02096k · Cited by 61
Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane
May, J. M., Sherman, D. J., Simpson, B. W., Ruiz, N., & Kahne, D. E. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0027 · Cited by 59
“The spread of antibiotic resistance, coupled with a sparse pipeline for new antibiotics, is one of the most serious threats facing medicine today [58, 59].”
Background
Catalytic and antimicrobial activities of magnetic nanoparticles supported N-heterocyclic palladium(II) complex: A magnetically recyclable catalyst for the treatment of environmental contaminants in aqueous media
Sajjadi, M., Nasrollahzadeh, M., & Tahsili, M. R. (2019) · Separation and Purification Technology · doi:10.1016/j.seppur.2019.115716 · Cited by 61
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents
Seefeld, M. A., Miller, W. H., Newlander, K. A., Burgess, W. J., Payne, D. J., Rittenhouse, S. F., Moore, T. D., DeWolf, W. E., Keller, P. M., Qiu, X., et al. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00405-x · Cited by 61
Temporal Variability of Antibiotics Fluxes in Wastewater and Contribution from Hospitals
Coutu, S., Rossi, L., Barry, D. A., Rudaz, S. L., & Vernaz, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053592 · Cited by 61
“They are thought to foster bacterial resistance, for example [4–7].”
Background
Clinical Aspects of Antimicrobial Resistance
Virk, A., & Steckelberg, J. M. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.2.200 · Cited by 60

Authors: Neu, H. C.
Affiliations: Columbia University (US)
Corresponding author: Neu, Harold C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1992-08-21
Volume: 257
Issue: 5073
Pages: 1064-1073
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.257.5073.1064
OpenAlex: W1980595924
Cited by: 2,834
References: 109
Citations by year: 2026: 23 · 2025: 48 · 2024: 57 · 2023: 71 · 2022: 91 · 2021: 93 · 2020: 123 · 2019: 100 · 2018: 122 · 2017: 123 · 2016: 105 · 2015: 87 · 2014: 95 · 2013: 109 · 2012: 99
FWCI: 46.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: antibiotic resistance, bacterial resistance, plasmids, transposable elements, horizontal gene transfer, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus, Enterobacteriaceae, Pseudomonas, antibiotic overuse, hygiene, novel antimicrobial agents
MeSH terms: Anti-Bacterial Agents, Bacterial Infections, Cross Infection, Drug Resistance, Microbial, Enterobacteriaceae, Haemophilus influenzae, Humans, Staphylococcus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus

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