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Probing Single Molecule Dynamics
Abstract
The room temperature dynamics of single sulforhodamine 101 molecules dispersed on a glass surface are investigated on two different time scales with near-field optics. On the 10 -2 - to 10 2 -second time scale, intensity fluctuations in the emission from single molecules are examined with polarization measurements, providing insight into their spectroscopic properties. On the nanosecond time scale, the fluorescence lifetimes of single molecules are measured, and their excited-state energy transfer to the aluminum coating of the near-field probe is characterized. A movie of the time-resolved emission demonstrates the feasibility of fluorescence lifetime imaging with single molecule sensitivity, picosecond temporal resolution, and a spatial resolving power beyond the diffraction limit.
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Cited by
Ha, T., Enderle, T., Ogletree, D. F., Chemla, D. S., Selvin, P. R., & Weiss, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6264 · Cited by 1,242
Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy
Zrimsek, A. B., Chiang, N., Mattei, M., Zaleski, S., McAnally, M. O., Chapman, C. T., Henry, A.-I., Schatz, G. C., & Van Duyne, R. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00552 · Cited by 720
Fort, E., & Grésillon, S. (2008) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/41/1/013001 · Cited by 697
Probing Individual Molecules with Confocal Fluorescence Microscopy
Nie, S., Chiu, D. T., & Zare, R. N. (1994) · Science · doi:10.1126/science.7973650 · Cited by 549
Bout, D. A. V., Yip, W.-T., Hu, D., Fu, D.-K., Swager, T. M., & Barbara, P. F. (1997) · Science · doi:10.1126/science.277.5329.1074 · Cited by 521
Metadata
- Authors
- Xie, X. S., & Dunn, R. C.
- Venue
- Science
- Published
- 1994-07-15
- Volume
- 265
- Issue
- 5170
- Pages
- 361-364
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978932116
- Cited by
- 582
- References
- 0
- FWCI
- 28.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
