The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Conformation of Macromolecules in the Gas Phase: Use of Matrix-Assisted Laser Desorption Methods in Ion Chromatography
Abstract
Conformational data for macromolecules in the gas phase have been obtained by the coupling of a matrix-assisted laser desorption ion source to an ion chromatograph. A series of polyethylene glycol (PEG) polymers "cationized" (converted to a cation) by sodium ions (Na + PEG9 to Na + PEG19) and a protonated neurotransmitter protein, bradykinin, were studied. Mobilities of Na + PEG9 to Na + PEG19 are reported. Detailed modeling of Na + PEG9 with molecular mechanics methods indicates that the lowest energy structure has the Na + ion "solvated" by the polymer chain with seven oxygen atoms as nearest neighbors. The agreement between the model and experiment is within 1 percent for Na + PEG9, Na + PEG13, and Na + PEG17, giving strong support to both the method and the deduced structures. Similar agreement was obtained in initial studies that modeled experimental data for arginine-protonated bradykinin.
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Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Cited by
Lanucara, F., Holman, S. W., Gray, C. J., & Eyers, C. E. (2014) · Nature Chemistry · doi:10.1038/nchem.1889 · Cited by 901
Gas-Phase Conformation of Biological Molecules: Bradykinin
Wyttenbach, T., von Helden, G., & Bowers, M. T. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9535928 · Cited by 384
Self-citationIon mobility–mass spectrometry: a new paradigm for proteomics
McLean, J. A., Ruotolo, B. T., Gillig, K. J., & Russell, D. H. (2005) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.10.003 · Cited by 309
Ion mobility in the pharmaceutical industry: an established biophysical technique or still niche?
Campuzano, I. D., & Lippens, J. L. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.11.008 · Cited by 42
Wang, X., Norgate, E., Dai, J., Benoit, F., Bristow, T., England, R. M., Kalapothakis, J. M. D., & Barran, P. E. (2025) · Nature Communications · doi:10.1038/s41467-025-59065-x · Cited by 7
Metadata
- Authors
- von Helden, G., Wyttenbach, T., & Bowers, M. T.
- Venue
- Science
- Published
- 1995-03-10
- Volume
- 267
- Issue
- 5203
- Pages
- 1483-1485
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014140929
- Cited by
- 363
- References
- 1
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- von Helden, G., Wyttenbach, T., & Bowers, M. T. (1995). Conformation of Macromolecules in the Gas Phase: Use of Matrix-Assisted Laser Desorption Methods in Ion Chromatography. Science. https://doi.org/10.1126/science.267.5203.1483
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
