The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Defective Lymphoid Development in Mice Lacking Jak3
Abstract
The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ (γ c ) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γ c signaling and lymphoid development.
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Metadata
- Authors
- Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C., & Ihle, J. N.
- Venue
- Science
- Published
- 1995-11-03
- Volume
- 270
- Issue
- 5237
- Pages
- 800-802
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012408584
- Cited by
- 637
- References
- 23
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C., & Ihle, J. N. (1995). Defective Lymphoid Development in Mice Lacking Jak3. Science. https://doi.org/10.1126/science.270.5237.800
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