The DOI matches its Crossref record.
Rhythmic Expression of timeless : A Basis for Promoting Circadian Cycles in period Gene Autoregulation
Abstract
The clock gene timeless ( tim ) is required for circadian rhythmicity in Drosophila . The accumulation of tim RNA followed a circadian rhythm, and the phase and period of the tim RNA rhythm were indistinguishable from those that have been reported for per . The tim RNA oscillations were found to be dependent on the presence of PER and TIM proteins, which demonstrates feedback control of tim by a mechanism previously shown to regulate per expression. The cyclic expression of tim appears to dictate the timing of PER protein accumulation and nuclear localization, suggesting that tim promotes circadian rhythms of per and tim transcription by restricting per RNA and PER protein accumulation to separate times of day.
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Citations
Cited by
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Circadian rhythms and the molecular clock in cardiovascular biology and disease
Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0167-4 · Cited by 499
Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra
Zhang, L., Hastings, M. H., Green, E. W., Tauber, E., Sladek, M., Webster, S. G., Kyriacou, C. P., & Wilcockson, D. C. (2013) · Current Biology · doi:10.1016/j.cub.2013.08.038 · Cited by 187
Metadata
- Authors
- Sehgal, A., Rothenfluh-Hilfiker, A., Hunter-Ensor, M., Chen, Y., Myers, M. P., & Young, M. W.
- Venue
- Science
- Published
- 1995-11-03
- Volume
- 270
- Issue
- 5237
- Pages
- 808-810
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056393772
- Cited by
- 369
- References
- 0
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rhythmic Expression of timeless : A Basis for Promoting Circadian Cycles in period Gene Autoregulation. https://app.cochat.ai/papers/10.1126/science.270.5237.808
- The paper
- Sehgal, A., Rothenfluh-Hilfiker, A., Hunter-Ensor, M., Chen, Y., Myers, M. P., & Young, M. W. (1995). Rhythmic Expression of timeless : A Basis for Promoting Circadian Cycles in period Gene Autoregulation. Science. https://doi.org/10.1126/science.270.5237.808
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
