The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest
Abstract
Yeast checkpoint control genes were found to affect processing of DNA damage as well as cell cycle arrest. An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24 , and MEC3 activated an exonuclease that degrades DNA. The degradation is probably a direct consequence of checkpoint protein function, because RAD17 encodes a putative 3′-5′ DNA exonuclease. Another checkpoint gene, RAD9 , had a different role: It inhibited the degradation by RAD17 , RAD24 , and MEC3 . A model of how processing of DNA damage may be linked to both DNA repair and cell cycle arrest is proposed.
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Citations
Cites
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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
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The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
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Self-citationLoss of a yeast telomere: Arrest, recovery, and chromosome loss
Sandell, L. (1993) · Cell · doi:10.1016/0092-8674(93)90493-a · Cited by 786
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Self-citationDifferential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
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Cited by
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Protection of mammalian telomeres
de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874
Metadata
- Authors
- Lydall, D., & Weinert, T.
- Venue
- Science
- Published
- 1995-12
- Volume
- 270
- Issue
- 5241
- Pages
- 1488-1491
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015821968
- Cited by
- 416
- References
- 26
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lydall, D., & Weinert, T. (1995). Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest. Science. https://doi.org/10.1126/science.270.5241.1488
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
