Cited by 585DNA Repair MechanismsFungal and yeast genetics researchCancer-related Molecular Pathways

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Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

Sanchez, Yolanda, Desany, Brian A., Jones, William J., Liu, Qinghua, Wang, Bin, Elledge, Stephen J.·1996·Science

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Abstract

Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated ( ATM ) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced. MEC1 and a structurally related gene, TEL1 , have overlapping functions in response to DNA damage and replication blocks that in mutants can be provided by overproduction of RAD53 . Both MEC1 and TEL1 were found to control phosphorylation of Rad53p in response to DNA damage. These results indicate that RAD53 is a signal transducer in the DNA damage and replication checkpoint pathways and functions downstream of two members of the ATM lipid kinase family. Because several members of this pathway are conserved among eukaryotes, it is likely that a RAD53 -related kinase will function downstream of the human ATM gene product and play an important role in the mammalian response to DNA damage.

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Authors: Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J.
Affiliations: Verna and Mars McLean Department of Biochemistry, Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Howard Hughes Medical Institute (US)
Corresponding author: Elledge, Stephen J.
ORCID: Liu, Qinghua
Wang, Bin
Elledge, Stephen J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-01-19
Volume: 271
Issue: 5247
Pages: 357-360
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5247.357
OpenAlex: W2102433010
Cited by: 585
References: 32
Citations by year: 2026: 3 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 6 · 2017: 13 · 2016: 19 · 2015: 15 · 2014: 15 · 2013: 14 · 2012: 12
FWCI: 13.63
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM-44664)
National Institute of Diabetes and Digestive and Kidney Diseases (DK07696, T32DK007696)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: Rad53, Mec1, Tel1, DNA damage checkpoint, S-phase checkpoint, Saccharomyces cerevisiae, signal transduction, DNA damage response, replication block
MeSH terms: Base Sequence, Cell Cycle, DNA Damage, DNA Replication, DNA-Binding Proteins, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Mutation, Phosphorylation, Protein Kinases, Proteins, Saccharomyces cerevisiae, Signal Transduction, Gene Expression Regulation, Fungal, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins, Ataxia Telangiectasia Mutated Proteins, Checkpoint Kinase 2

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Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

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