The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells
Abstract
T cells activated by antigen receptor stimulation in the absence of accessory cell-derived costimulatory signals lose the capacity to synthesize the growth factor interleukin-2 (IL-2), a state called clonal anergy. An analysis of CD3- and CD28-induced signal transduction revealed reduced ERK and JNK enzyme activities in murine anergic T cells. The amounts of ERK and JNK proteins were unchanged, and the kinases could be fully activated in the presence of phorbol 12-myristate 13-acetate. Dephosphorylation of the calcineurin substrate NFATp (preexisting nuclear factor of activated T cells) also remained inducible. These results suggest that a specific block in the activation of ERK and JNK contributes to defective IL-2 production in clonal anergy.
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Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
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Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
Marengère, L. E. M., Waterhouse, P., Duncan, G. S., Mittrücker, H.-W., Feng, G.-S., & Mak, T. W. (1996) · Science · doi:10.1126/science.272.5265.1170 · Cited by 551
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
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E3 ubiquitin ligases as T cell anergy factors
Mueller, D. L. (2004) · Nature Immunology · doi:10.1038/ni1106 · Cited by 224
Self-citationBandyopadhyay, S., Duré, M., Paroder, M., Soto-Nieves, N., Puga, I., & Macián, F. (2007) · Blood · doi:10.1182/blood-2006-07-037754 · Cited by 104
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Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
Soto-Nieves, N., Puga, I., Abe, B. T., Bandyopadhyay, S., Baine, I., Rao, A., & Macian, F. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082731 · Cited by 86
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Learning from the nexus of autoimmunity and cancer
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Metadata
- Authors
- Li, W., Whaley, C. D., Mondino, A., & Mueller, D. L.
- Venue
- Science
- Published
- 1996-03
- Volume
- 271
- Issue
- 5253
- Pages
- 1272-1276
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036510457
- Cited by
- 427
- References
- 1
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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