Cited by 683Fungal and yeast genetics researchIron Metabolism and DisordersPlant Micronutrient Interactions and Effects

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A permease-oxidase complex involved in high-affinity iron uptake in yeast.

Stearman, Robert, Yuan, Daniel S., Yamaguchi-Iwai, Yuko, Klausner, Richard D., Dancis, Andrew·1996·Science

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Abstract

Iron must cross biological membranes to reach essential intracellular enzymes. Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake. FET3 expression was required for FTR1 protein to be transported to the plasma membrane. FTR1 expression was required for apo-FET3 protein to be loaded with copper and thus acquire oxidase activity. FTR1 protein also played a direct role in iron transport. Mutations in a conserved sequence motif of FTR1 specifically blocked iron transport.

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Authors: Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A.
Affiliations: National Institutes of Health (US)
Cell Biology and Metabolism Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Corresponding author: Dancis, Andrew
ORCID: Stearman, Robert
Yuan, Daniel S.
Dancis, Andrew
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-03-15
Volume: 271
Issue: 5255
Pages: 1552-1557
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5255.1552
OpenAlex: W2005806732
Cited by: 683
References: 45
Citations by year: 2026: 9 · 2025: 16 · 2024: 15 · 2023: 12 · 2022: 26 · 2021: 22 · 2020: 12 · 2019: 10 · 2018: 17 · 2017: 14 · 2016: 13 · 2015: 19 · 2014: 18 · 2013: 21 · 2012: 16
FWCI: 16.55
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords: iron absorption, multicopper oxidase, iron permease, plasma membrane transport, copper loading, yeast, conserved motifs
MeSH terms: Amino Acid Sequence, Binding Sites, Biological Transport, Carrier Proteins, Cell Membrane, Ceruloplasmin, Copper, Endoplasmic Reticulum, Ferric Compounds, Ferritins, Ferrous Compounds, Genes, Fungal, Golgi Apparatus, Iron, Models, Biological, Molecular Sequence Data, Multienzyme Complexes, Mutation, Oxidation-Reduction, Oxidoreductases, Saccharomyces cerevisiae, Transformation, Genetic, Open Reading Frames, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins

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A permease-oxidase complex involved in high-affinity iron uptake in yeast.

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