The DOI matches its Crossref record.
Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled
Abstract
In Drosophila , the Wingless and Notch signaling pathways function in many of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Wingless signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.
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Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Self-citationWnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
Brack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., & Rando, T. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.10.006 · Cited by 682
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656
Metadata
- Authors
- Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S., & Perrimon, N.
- Venue
- Science
- Published
- 1996-03-29
- Volume
- 271
- Issue
- 5257
- Pages
- 1826-1832
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2139936955
- Cited by
- 418
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S., & Perrimon, N. (1996). Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled. Science. https://doi.org/10.1126/science.271.5257.1826
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
