The DOI matches its Crossref record.
Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled
Abstract
In Drosophila , the Wingless and Notch signaling pathways function in many of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Wingless signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.
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Citations
Cited by
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Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
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Metadata
- Authors
- Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S., & Perrimon, N.
- Venue
- Science
- Published
- 1996-03-29
- Volume
- 271
- Issue
- 5257
- Pages
- 1826-1832
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2139936955
- Cited by
- 418
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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