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Cited by 696

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 WAF1/CIP1 Mediated by STAT1

Chin, Yue E., Kitagawa, Motoo, Su, Wu-Chou S., You, Zhi-Hao, Iwamoto, Yoshiki, Fu, Xin-Yuan·1996·Science
DOI 10.1126/science.272.5262.719
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Abstract

Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-γ. STAT activation was correlated with cell growth inhibition in response to EGF and IFN-γ. Activated STAT proteins specifically recognized the conserved STAT-responsive elements in the promoter of the gene encoding the cyclin-dependent kinase (CDK) inhibitor p21 WAF1/CIP1 and regulated the induction of p21 messenger RNA. IFN-γ did not inhibit the growth of U3A cells, which are deficient in STAT1, but did inhibit the growth of U3A cells into which STAT1α was reintroduced. Thus, STAT1 protein is essential for cell growth suppression in response to IFN-γ. The STAT signaling pathway appears to negatively regulate the cell cycle by inducing CDK inhibitors in response to cytokines.

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Crossref · 10.1126/science.272.5262.719

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 38

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Cited by

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Metadata

Authors
Chin, Y. E., Kitagawa, M., Su, W.-C. S., You, Z.-H., Iwamoto, Y., & Fu, X.-Y.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-05-03
Volume
272
Issue
5262
Pages
719-722
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5262.719
Cited by
696
References
3
Language
en

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