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Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

Torres, Raul M., Flaswinkel, Heinrich, Reth, Michael, Rajewsky, Klaus·1996·Science
DOI 10.1126/science.272.5269.1804
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Abstract

The immunoglobulin α (Ig-α)-Ig-β heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-α cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-α signaling in antibody responses such that a signaling-competent Ig-α appears to be critical for the response to T-independent, but not T-dependent, antigens.

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Metadata

Authors
Torres, R. M., Flaswinkel, H., Reth, M., & Rajewsky, K.
Affiliations
  • R. M. Torres and K. Rajewsky, Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.
  • H. Flaswinkel and M. Reth, Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-06-21
Volume
272
Issue
5269
Pages
1804-1808
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5269.1804
Cited by
207
References
0
Language
en

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CoChat. (2026). Citation check: Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex. https://app.cochat.ai/papers/10.1126/science.272.5269.1804
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Torres, R. M., Flaswinkel, H., Reth, M., & Rajewsky, K. (1996). Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex. Science. https://doi.org/10.1126/science.272.5269.1804