The DOI matches its Crossref record.
T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds
Abstract
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of antigen-presenting cell, and the nature of the T cell receptor (TCR) ligand. A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells "counted" the number of triggered TCRs and responded when a threshold of ∼8000 TCRs was reached. The capacity to reach the activation threshold was severely compromised by a reduction in the number of TCRs. Costimulatory signals lowered the activation threshold to ∼1500 TCRs, thus making T cells more sensitive to antigenic stimulation.
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Citations
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Metadata
- Authors
- Viola, A., & Lanzavecchia, A.
- Venue
- Science
- Published
- 1996-07-05
- Volume
- 273
- Issue
- 5271
- Pages
- 104-106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092643850
- Cited by
- 1,023
- References
- 0
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- closed
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