The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice
Abstract
Allogeneic transplantation of islets of Langerhans was facilitated by the cotransplantation of syngeneic myoblasts genetically engineered to express the Fas ligand (FasL). Composite grafting of allogeneic islets with syngeneic myoblasts expressing FasL protected the islet graft from immune rejection and maintained normoglycemia for more than 80 days in mice with streptozotocin-induced diabetes. Graft survival was not prolonged with composite grafts of unmodified myoblasts or Fas-expressing myoblasts. Islet allografts transplanted separately from FasL-expressing myoblasts into the contralateral kidney were rejected, as were similarly transplanted third-party thyroid allografts. Thus, the FasL signal provided site- and immune-specific protection of islet allografts.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Lethal effect of the anti-Fas antibody in mice
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Cited by
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,938
Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape
Hahne, M., Rimoldi, D., Schröter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., et al. (1996) · Science · doi:10.1126/science.274.5291.1363 · Cited by 1,249
Self-citationMaldonado-López, R., De Smedt, T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Leo, O., Urbain, J., & Moser, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.587 · Cited by 984
To Die or Not to Die: An Overview of Apoptosis and Its Role in Disease
Hetts, S. W. (1998) · JAMA · doi:10.1001/jama.279.4.300 · Cited by 507
Kang, S.-M., Schneider, D. B., Lin, Z., Hanahan, D., Dichek, D. A., Stock, P. G., & Baekkeskov, S. (1997) · Nature Medicine · doi:10.1038/nm0797-738 · Cited by 450
Metadata
- Authors
- Lau, H. T., Yu, M., Fontana, A., & Stoeckert, C. J.
- Venue
- Science
- Published
- 1996-07-05
- Volume
- 273
- Issue
- 5271
- Pages
- 109-112
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078901980
- Cited by
- 445
- References
- 2
- FWCI
- 84.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lau, H. T., Yu, M., Fontana, A., & Stoeckert, C. J. (1996). Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice. Science. https://doi.org/10.1126/science.273.5271.109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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