The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
To Die or Not to Die: An Overview of Apoptosis and Its Role in Disease
Abstract
The death of cells in tissues of humans and other multicellular organisms is neither always abnormal nor always detrimental. Although necrosis ensues at the sites of massive cellular injury, most cells in the body die through a more subtle, noninflammatory, energy-dependent form of cell death called apoptosis. The number of cells in tissues is determined by the homeostatic balance between proliferation of new cells and death of senescent cells; the rates of proliferation and apoptosis vary widely from tissue to tissue. Recent research into the molecular mechanisms of apoptosis has revealed that apoptosis is a genetically programmed process that can become deranged when the components of the cellular apoptotic machinery are mutated or present in inappropriate quantities. Dysregulation of apoptosis is associated with the pathogenesis of a wide array of diseases: cancer, neurodegeneration, autoimmunity, heart disease, and other disorders. Products of genes involved in the regulation and execution of apoptosis are potentially excellent targets for diagnosis and therapeutic intervention in disease processes, and they offer renewed hope for cures and treatments for a wide array of maladies.
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Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
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p53, the cellular gatekeeper for growth and division
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Apoptosis in the Pathogenesis and Treatment of Disease
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Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
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Cited by
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Nicholson, D. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400598 · Cited by 1,543
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
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Apoptosis and apoptotic body: disease message and therapeutic target potentials
Xu, X., Lai, Y., & Hua, Z.-C. (2019) · Bioscience Reports · doi:10.1042/bsr20180992 · Cited by 909
Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
FADEEL, B., & ORRENIUS, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 698
Metadata
- Authors
- Hetts, S. W.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1998-01-28
- Volume
- 279
- Issue
- 4
- Pages
- 300
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2040266344
- Cited by
- 507
- References
- 75
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hetts, S. W. (1998). To Die or Not to Die: An Overview of Apoptosis and Its Role in Disease. JAMA. https://doi.org/10.1001/jama.279.4.300
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
