The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
Abstract
The CDC13 gene has previously been implicated in the maintenance of telomere integrity in Saccharomyces cerevisiae . With the use of two classes of mutations, here it is shown that CDC13 has two discrete roles at the telomere. The cdc13-2 est mutation perturbs a function required in vivo for telomerase regulation but not in vitro for enzyme activity, whereas cdc13-1 ts defines a separate essential role at the telomere. In vitro, purified Cdc13p binds to single-strand yeast telomeric DNA. Therefore, Cdc13p is a telomere-binding protein required to protect the telomere and mediate access of telomerase to the chromosomal terminus.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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Telomeres shorten during ageing of human fibroblasts
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Self-citationA mutant with a defect in telomere elongation leads to senescence in yeast
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Self-citationActivation of telomerase in human lymphocytes and hematopoietic progenitor cells
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TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase
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Cited by
Cell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,039
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
TRF2 Protects Human Telomeres from End-to-End Fusions
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Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., & Cech, T. R. (1997) · Science · doi:10.1126/science.276.5312.561 · Cited by 1,269
Self-citationProtection of mammalian telomeres
de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942
Metadata
- Authors
- Nugent, C. I., Hughes, T. R., Lue, N. F., & Lundblad, V.
- Venue
- Science
- Published
- 1996-10-11
- Volume
- 274
- Issue
- 5285
- Pages
- 249-252
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988669405
- Cited by
- 598
- References
- 26
- FWCI
- 20.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance. https://app.cochat.ai/papers/10.1126/science.274.5285.249
- The paper
- Nugent, C. I., Hughes, T. R., Lue, N. F., & Lundblad, V. (1996). Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance. Science. https://doi.org/10.1126/science.274.5285.249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
