The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Crystal Structure of a Five-Stranded Coiled Coil in COMP: A Prototype Ion Channel?
Abstract
Oligomerization by the formation of α-helical bundles is common in many proteins. The crystal structure of a parallel pentameric coiled coil, constituting the oligomerization domain in the cartilage oligomeric matrix protein (COMP), was determined at 2.05 angstroms resolution. The same structure probably occurs in two other extracellular matrix proteins, thrombospondins 3 and 4. Complementary hydrophobic interactions and conserved disulfide bridges between the α helices result in a thermostable structure with unusual properties. The long hydrophobic axial pore is filled with water molecules but can also accommodate small apolar groups. An “ion trap” is formed inside the pore by a ring of conserved glutamines, which binds chloride and probably other monatomic anions. The oligomerization domain of COMP has marked similarities with proposed models of the pentameric transmembrane ion channels in phospholamban and the acetylcholine receptor.
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Citations
Cites
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490
Crystal structure of an isoleucine-zipper trimer
Harbury, P. B., Kim, P. S., & Alber, T. (1994) · Nature · doi:10.1038/371080a0 · Cited by 472
The Fourier transform of a coiled-coil
Crick, F. H. C. (1953) · Acta Crystallographica · doi:10.1107/s0365110x53001952 · Cited by 313
Cited by
Yashima, E., Ousaka, N., Taura, D., Shimomura, K., Ikai, T., & Maeda, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00354 · Cited by 2,004
MultiCoil: A program for predicting two‐and three‐stranded coiled coils
Wolf, E., Kim, P. S., & Berger, B. (1997) · Protein Science · doi:10.1002/pro.5560060606 · Cited by 720
Walshaw, J., & Woolfson, D. N. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4545 · Cited by 357
Computational design of water-soluble α-helical barrels
Thomson, A. R., Wood, C. W., Burton, A. J., Bartlett, G. J., Sessions, R. B., Brady, R. L., & Woolfson, D. N. (2014) · Science · doi:10.1126/science.1257452 · Cited by 330
Tuning the erosion rate of artificial protein hydrogels through control of network topology
Shen, W., Zhang, K., Kornfield, J. A., & Tirrell, D. A. (2006) · Nature Materials · doi:10.1038/nmat1573 · Cited by 294
Metadata
- Authors
- Malashkevich, V. N., Kammerer, R. A., Efimov, V. P., Schulthess, T., & Engel, J.
- Venue
- Science
- Published
- 1996-11
- Volume
- 274
- Issue
- 5288
- Pages
- 761-765
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029774675
- Cited by
- 299
- References
- 3
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Malashkevich, V. N., Kammerer, R. A., Efimov, V. P., Schulthess, T., & Engel, J. (1996). The Crystal Structure of a Five-Stranded Coiled Coil in COMP: A Prototype Ion Channel? Science. https://doi.org/10.1126/science.274.5288.761
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