The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Hyperresponsive B Cells in CD22-Deficient Mice
Abstract
CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.
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Cites
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Cited by
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
Calcium signalling in lymphocyte activation and disease
Feske, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2152 · Cited by 1,043
Siglecs as Immune Cell Checkpoints in Disease
Duan, S., & Paulson, J. C. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102419-035900 · Cited by 452
Chan, V. W. F., Meng, F., Soriano, P., DeFranco, A. L., & Lowell, C. A. (1997) · Immunity · doi:10.1016/s1074-7613(00)80511-7 · Cited by 451
GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Kurosaki, T. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.555 · Cited by 432
Metadata
- Authors
- O'Keefe, T. L., Williams, G. T., Davies, S. L., & Neuberger, M. S.
- Venue
- Science
- Published
- 1996-11
- Volume
- 274
- Issue
- 5288
- Pages
- 798-801
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996486759
- Cited by
- 532
- References
- 33
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- O'Keefe, T. L., Williams, G. T., Davies, S. L., & Neuberger, M. S. (1996). Hyperresponsive B Cells in CD22-Deficient Mice. Science. https://doi.org/10.1126/science.274.5288.798
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
