Cited by 287HIV Research and TreatmentTelomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover

Wolthers, Katja C., Bea, G., Wisman, A., Otto, Sigrid A., de Roda Husman, Ana-Maria, Schaft, Niels, de Wolf, Frank, Goudsmit, Jaap, Coutinho, Roel A., van der Zee, Ate G. J., Meyaard, Linde, Miedema, Frank·1996·Science

DOI 10.1126/science.274.5292.1543

Open this paper in CoChat — free account

Abstract

Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8 + T cell TRF length decreased but CD4 + T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8 + T cells, but not in CD4 + T cells. These results are compatible with CD4 + T cell decline in HIV-1 infection caused by interference with cell renewal.

Integrity signals

Registry

Crossref · 10.1126/science.274.5292.1543

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M., & Markowitz, M. H. (1995) · Nature · doi:10.1038/373123a0 · Cited by 4,261
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
Perelson, A. S., Neumann, A. U., Markowitz, M. H., Leonard, J. M., & Ho, D. D. (1996) · Science · doi:10.1126/science.271.5255.1582 · Cited by 3,533
Viral dynamics in human immunodeficiency virus type 1 infection
Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., et al. (1995) · Nature · doi:10.1038/373117a0 · Cited by 3,259
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096
Untitled work
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847

Flagged first, then by citations

Show all 58 references

Research works printed but not linked: 7

Bofill M., et al., ibid. 10, 827 (1996).
Gougeon M., Montagnier L., ibid. 260, 1269 (1993);
Muro-Cacho C. A., Pantaleo G., Fauci A. S., ibid. 154, 5555 (1995).
Morin G. B., ibid. 59, 521 (1989);
Vaziri H., et al., Am. J. Hum. Genet. 52, 661 (1993).
Slagboom P. E., Droog S., Boomsma D. I., Am. J. Hum. Genet. 55, 876 (1994).
De Lange T., et al., Mol. Cell. Biol. 10, 518 (1990).

Sorted by citations

Items 101–200 of 287

Hydroxyurea and HIV: 5 years later-from antiviral to immune-modulating effects
Lori, F. (1999) · AIDS · doi:10.1097/00002030-199908200-00001 · Cited by 51
Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere loss
Thornley, I., Sutherland, R., Wynn, R. F., Nayar, R., Sung, L., Corpus, G., Kiss, T. L., Lipton, J. H., Doyle, J., Saunders, F., et al. (2002) · Blood · doi:10.1182/blood.v99.7.2387 · Cited by 51
How does HIV cause AIDS? The homing theory
Cloyd, M. W., Chen, J. J.-Y., & Wang, L. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01663-9 · Cited by 48
The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse
Nan-PIng, W., & Hodes, R. J. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1017223602293 · Cited by 49
Human Immunodeficiency Virus Type 1 Induces Apoptosis in CD4+but Not in CD8+T Cells in Ex Vivo-Infected Human Lymphoid Tissue
Grivel, J., Malkevitch, N., & Margolis, L. B. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8077-8084.2000 · Cited by 49
Human Immunodeficiency Virus Type 1 Modulates Telomerase Activity in Peripheral Blood Lymphocytes
Ballon, G., Ometto, L., Righetti, E., Cattelan, A. M., Masiero, S., Zanchetta, M., Chieco‐Bianchi, L., & Rossi, A. D. (2001) · The Journal of Infectious Diseases · doi:10.1086/318072 · Cited by 52
Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users
Yu, X., Wang, Z., Vlahov, D., Markham, R. B., Farzadegan, H., & Margolick, J. B. (1998) · The Journal of Infectious Diseases · doi:10.1086/515646 · Cited by 49
Immunopathologic changes in the thymus during the acute stage of experimentally induced feline immunodeficiency virus infection in juvenile cats
Woo, J. C., Dean, G. A., Pedersen, N. C., & Moore, P. F. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8632-8641.1997 · Cited by 49
Mechanisms of immune aging in HIV
Chauvin, M., & Sauce, D. (2022) · Clinical Science · doi:10.1042/cs20210344 · Cited by 50
Immune Reconstitution in Patients with HIV Infection
Sempowski, G. D., & Haynes, B. F. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104032 · Cited by 48
Mathematics in modern immunology
Castro, M., Lythe, G., Molina-Parı́s, C., & Ribeiro, R. M. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0093 · Cited by 49
HIV-Induced Changes in T Cell Signaling Pathways
Schweneker, M., Favre, D., Martin, J. N., Deeks, S. G., & McCune, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6490 · Cited by 46
Recovery of Hematopoietic Activity in Bone Marrow from Human Immunodeficiency Virus Type 1-Infected Patients during Highly Active Antiretroviral Therapy
Isgrò, A., Mezzaroma, I., Aiuti, A., Vita, L. D., Franchi, F., Pandolfi, F., Alario, C., Ficara, F., Riva, E., Antonelli, G., et al. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/088922200750005994 · Cited by 45
Induction of HIV-1-specific T cell responses by administration of cytokines in late-stage patients receiving highly active anti-retroviral therapy
Imami, N., Hardy, G. A. D., Nelson, M. R., Morris-Jones, S. D., Salman, R. A., Antonopoulos, C., Gazzard, C. M., & Gotch, F. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01012.x · Cited by 46
Ineffective Cellular Immune Response Associated with T-Cell Apoptosis in SusceptibleMycobacterium bovisBCG-Infected Mice
Kremer, L., Estaquier, J., Wolowczuk, I., Biet, F., Ameisen, J., & Locht, C. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.4264-4273.2000 · Cited by 46
CD4 lymphocytes in the blood of HIV+ individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion
Chen, J. J.-Y., Huang, J. C., Shirtliff, M. E., BRISCOE, E. G., ALI, S. A., CESANI, F., Paar, D. P., & Cloyd, M. W. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.271 · Cited by 46
Regulation of telomerase activity by apparently opposing elements
Liu, J., Chen, S., Cong, Y.-S., Nicholls, C., Zhou, S.-F., Tao, Z., & Li, H. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.03.002 · Cited by 45
Stochastic models of telomere shortening
Olofsson, P., & Kimmel, M. (1999) · Mathematical Biosciences · doi:10.1016/s0025-5564(98)10092-5 · Cited by 43
Telomeres And Telomerase in Adult Stem Cells and Pluripotent Embryonic Stem Cells
Marión, R. M., & Blasco, M. A. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7037-4_9 · Cited by 46
T Cell Renewal Rates, Telomerase, and Telomere Length Shortening
de Boer, R. J., & Noest, A. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5832 · Cited by 42
New Uses for Old Drugs in HIV Infection
Ravot, E., Lisziewicz, J., & Lori, F. (1999) · Drugs · doi:10.2165/00003495-199958060-00001 · Cited by 40
Flow cytometric measurement of telomere length
Lauzon, W., Sanchez-Dardon, J. L., Cameron, D. W., & Badley, A. D. (2000) · Cytometry · doi:10.1002/1097-0320(20000615)42:3 · Cited by 38
Activation of CD8 T cells normalizes and correlates with the level of infectious provirus in tonsils during highly active antiretroviral therapy in early HIV-1 infection
Dyrhol‐Riise, A. M., Voltersvik, P., Olofsson, J. S., & Åsjö, B. (1999) · AIDS · doi:10.1097/00002030-199912030-00008 · Cited by 40
Distinct Cycling CD4+- and CD8+-T-Cell Profiles during the Asymptomatic Phase of Simian Immunodeficiency Virus SIVmac251 Infection in Rhesus Macaques
Monceaux, V., Fang, R. H. T., Cumont, M., Hurtrel, B., & Estaquier, J. (2003) · Journal of Virology · doi:10.1128/jvi.77.18.10047-10059.2003 · Cited by 37
Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
Klein, M. R., van der Burg, S. H., Pontesilli, O., & Miedema, F. F. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01288-2 · Cited by 37
Self-citation
Telomerase and Telomeres: From Basic Biology to Cancer Treatment
Helder, M. N., Wisman, G. B. A., & van der Zee, A. G. J. (2002) · Cancer Investigation · doi:10.1081/cnv-120000370 · Cited by 37
Shorter Telomere Length - A Potential Susceptibility Factor for HIV-Associated Neurocognitive Impairments in South African Woman
Malan‐Müller, S., Hemmings, S. M. J., Spies, G., Kidd, M., Fennema‐Notestine, C., & Seedat, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058351 · Cited by 36
Pathogen burden and leukocyte telomere length in the United States
Noppert, G. A., Feinstein, L., Dowd, J. B., Stebbins, R. C., Zang, E. X., Needham, B. L., Meier, H. C. S., Simanek, A. M., & Aiello, A. E. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00206-9 · Cited by 36
Progressive Telomere Shortening of Epstein‐Barr Virus–Specific Memory T Cells during HIV Infection: Contributor to Exhaustion?
van Baarle, D., Nanlohy, N. M., Otto, S. A., Plunkett, F. J., Fletcher, J. M., & Akbar, A. N. (2008) · The Journal of Infectious Diseases · doi:10.1086/592170 · Cited by 35
Self-citation
Goals and milestones during treatment of HIV-1 infection with antiretroviral therapy: a pathogenesis-based perspective
Louie, M. J., & Markowitz, M. H. (2002) · Antiviral Research · doi:10.1016/s0166-3542(02)00022-0 · Cited by 36
Rapid Decrease in Peripheral Blood Mononucleated Cell Telomere Length After HIV Seroconversion, but Not HCV Seroconversion
González‐Serna, A., Ajaykumar, A., Gadawski, I., Muñoz‐Fernández, M. Á., Hayashi, K., Harrigan, P. R., & Côté, H. C. F. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001446 · Cited by 35
Increases in T Cell Telomere Length in HIV Infection after Antiretroviral Combination Therapy for HIV-1 Infection Implicate Distinct Population Dynamics in CD4+ and CD8+ T Cells
Kaushal, S., LANDAY, A. L., Lederman, M. M., Connick, E., Spritzler, J., Kuritzkes, D. R., Kessler, H. A., Levine, B. L., Louis, D. C. S., & June, C. H. (1999) · Clinical Immunology · doi:10.1006/clim.1999.4726 · Cited by 35
Mathematical Models and Immune Cell Biology
Molina-Parı́s, C., & Lythe, G. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7725-0 · Cited by 34
Distribution of Cycling T Lymphocytes in Blood and Lymphoid Organs During Immune Responses
Vasseur, F., Campion, A. L., Pavlovitch, J. H., & Pénit, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5164 · Cited by 33
HLA-class I-specific inhibitory receptors in HIV-1 infection
Maria, A. D., & Moretta, L. (2000) · Human Immunology · doi:10.1016/s0198-8859(99)00169-x · Cited by 33
Normal Telomere Lengths in Naive and Memory CD4+ T Cells in HIV Type 1 Infection: A Mathematical Interpretation
Wolthers, K. C., Noest, A. J., Otto, S. A., Miedema, F. F., & de Boer, R. J. (1999) · AIDS Research and Human Retroviruses · doi:10.1089/088922299310340 · Cited by 33
Self-citation
Rationale for the Use of Hydroxyurea as an Anti-Human Immunodeficiency Virus Drug
Lori, F., & Lisziewicz, J. (2000) · Clinical Infectious Diseases · doi:10.1086/313851 · Cited by 33
HIV infection and aging of the innate immune system
Hearps, A. C., Angelovich, T. A., Jaworowski, A., MILLS, J. S., LANDAY, A. L., & Crowe, S. M. (2011) · Sexual Health · doi:10.1071/sh11028 · Cited by 33
Herpes zoster infection as an immune reconstitution inflammatory syndrome in HIV-seropositive subjects: a review
Feller, L., Wood, N. H., & Lemmer, J. (2007) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2007.02.001 · Cited by 32
Telomeres and HIV disease
Effros, R. B. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00283-5 · Cited by 32
Analysis of telomere length and thymic output in fast and slow/non-progressors with HIV infection
Richardson, M. W., Sverstiuk, A. E., Hendel, H., Cheung, T., Zagury, J., & Rappaport, J. (2000) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(00)88637-0 · Cited by 33
Immune Restoration by Combination of a Cytostatic Drug (Hydroxyurea) and Anti-HIV Drugs (Didanosine and Indinavir)
Lori, F., Jessen, H. K., Lieberman, J., Clerici, M., Tinelli, C., & Lisziewicz, J. (1999) · AIDS Research and Human Retroviruses · doi:10.1089/088922299310917 · Cited by 32
The importance of lymphocyte trafficking in regulating blood lymphocyte levels during HIV and SIV infections
Rosenberg, Y. J., & Janossy, G. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0169 · Cited by 31
Current strategies in the treatment of HIV infection
Cohen, O. J., & Fauci, A. S. (2002) · Disease-a-Month · doi:10.1067/mda.2002.124659 · Cited by 30
The Burden of Image Based Emphysema and Bronchiolitis in HIV-Infected Individuals on Antiretroviral Therapy
Guaraldi, G., Besutti, G., Scaglioni, R., Santoro, A., Zona, S., Ligabue, G., Marchioni, A., Orlando, G., Carli, F., Beghé, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109027 · Cited by 31
Increased CD4+ T‐Lymphocyte Senescence Fraction in Advanced Human Immunodeficiency Virus Type 1 Infection
Nichols, W. S., SCHNEIDER, S., Chan, R. C., Farthing, C., & Daar, E. S. (1999) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1999.00505.x · Cited by 29
Telomere dynamics in Fancg-deficient mouse and human cells
Franco, S., van de Vrugt, H. J., Fernández, P., Aracil, M., Arwert, F., & Blasco, M. A. (2004) · Blood · doi:10.1182/blood-2003-10-3626 · Cited by 30
Hematopoietic cells and replicative senescence
Effros, R. B., & Globerson, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00183-8 · Cited by 29
Different Immunological Phenotypes Associated with Preserved CD4+ T Cell Counts in HIV-Infected Controllers and Viremic Long Term Non-Progressors
Gaardbo, J. C., Hartling, H. J., Ronit, A., Thorsteinsson, K., MADSEN, H. O., Springborg, K. K., Gjerdrum, L. M. R., Birch, C., Laye, M. J., Ullum, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063744 · Cited by 29
Shorter Telomere Length Predicts Poorer Immunological Recovery in Virologically Suppressed HIV-1–Infected Patients Treated With Combined Antiretroviral Therapy
Blanco, J. R., Jarrín, I., Martı́nez, A., Siles, E., Larráyoz, I. M., Cañuelo, A., Gutiérrez, F., González‐García, J., Vidal, F., & Moreno, S. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000398 · Cited by 28
Specific Changes in the Posttranslational Regulation of Nucleolin in Lymphocytes from Patients Infected with Human Immunodeficiency Virus
Galati, D., Paiardini, M., Cervasi, B., Albrecht, H., Bocchino, M., Costantini, A., Montroni, M., Magnani, M., Piedimonte, G., & Silvestri, G. (2003) · The Journal of Infectious Diseases · doi:10.1086/379249 · Cited by 28
Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics
Marchetti, G. C., Meroni, L., Molteni, C., Bandera, A., Franzetti, F., Galli, M., Moroni, M., Clerici, M., & Gori, A. (2004) · AIDS · doi:10.1097/00002030-200401230-00010 · Cited by 27
Telomeres and HIV-1 infection: in search of exhaustion
Wolthers, K. C., & Miedema, F. F. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01233-5 · Cited by 27
Self-citation
Long-term follow-up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic stem cell exhaustion
de Pauw, E. S. D., Otto, S. A., Wijnen, J., Vossen, J. M. J. J., van Weel-Sipman, M. H., Tanke, H. J., Miedema, F. F., Willemze, R., Roelofs, H., & Fibbe, W. E. (2002) · British Journal of Haematology · doi:10.1046/j.0007-1048.2001.03283.x · Cited by 27
Self-citation
Early T‐Cell Apoptosis and Fas Expression During Antiretroviral Therapy in Individuals Infected with Human Immunodeficiency Virus‐1
Aries, Weyrich, Schaaf, Hansen, Dennin, & Dalhoff (1998) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1998.00347.x · Cited by 27
T Cell Proliferation and Apoptosis in HIV-1-Infected Lymphoid Tissue: Impact of Highly Active Antiretroviral Therapy
Dyrhol‐Riise, A. M., Ohlsson, M., Skarstein, K., Nygaard, S. J. T., Olofsson, J. S., Jonsson, R., & Åsjö, B. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5102 · Cited by 26
Normal physiology and HIV pathophysiology of human T-cell dynamics
Richman, D. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9478 · Cited by 26
Telomeres in the Haemopoietic System
Lansdorp, P. M., Poon, S. S. S., Chavez, E. A., Dragowska, V., Zijlmans, M., Bryan, T. M., Reddel, R. R., Egholm, M., Bacchetti, S., & Martens, U. M. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515433.ch14 · Cited by 26
Clinical Impact of Telomere Length Testing for Interstitial Lung Disease
Zhang, D., Eckhardt, C. M., McGroder, C. F., Benesh, S., Porcelli, J., Depender, C., Bogyo, K., Westrich, J. A., Thomas‐Wilson, A., Jobanputra, V., et al. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.06.006 · Cited by 26
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors
dos Santos, P. R., Turnbull, E. L., Monteiro, M., Legrand, A., Conrod, K. E., Baalwa, J., Pellegrino, P., Shaw, G. M., Williams, I. G., Borrow, P., et al. (2012) · Blood · doi:10.1182/blood-2011-12-395186 · Cited by 24
Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection
Hudson, L. L., Markert, M. L., Devlin, B. H., Haynes, B. F., & Sempowski, G. D. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.002 · Cited by 24
Telomeres and Essential Hypertension
Aviv, A. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00202-7 · Cited by 24
Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection.
Wolthers, K. C., Otto, S. A., Wisman, G. B. A., Fleury, S., Reiss, P., ten Kate, R. W., van der Zee, A. G. J., & Miedema, F. F. (1999) · PubMed · Cited by 24
Self-citation
Dynamics of CD4+T cells in HIV‐1 infection
Ribeiro, R. M. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100056 · Cited by 24
No evidence for proliferation in the blood CD4+ T-cell pool during HIV-1 infection and triple combination therapy
Tissot, O., Viard, J., Rabian, C., Ngo‐Giang‐Huong, N., Burgard, M., Rouzioux, C., & Pénit, C. (1998) · AIDS · doi:10.1097/00002030-199808000-00010 · Cited by 24
Lymphocytes proliferate in blood and lymph nodes following interleukin-2 therapy in addition to highly active antiretroviral therapy
Hengge, U. R., Borchard, C., Eßer, S., Schröder, M., Mirmohammadsadegh, A., & Goos, M. (2002) · AIDS · doi:10.1097/00002030-200201250-00003 · Cited by 24
Mechanisms regulating expansion of CD 8+ T cells during HIV ‐1 infection
Nasi, A., & Chiodi, F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12722 · Cited by 24
Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: evidence for a major alteration within the CD8+ T cell subset
Sousa, A. E., & Victorino, R. M. M. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00585.x · Cited by 23
Lymph nodes during antiretroviral therapy
Stellbrink, H. J., & van Lunzen, J. (2001) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200102000-00004 · Cited by 22
S-phase entry leads to cell death in circulating T cells from HIV-infected persons
Sieg, S. F., Bazdar, D. A., & Lederman, M. M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907643 · Cited by 22
Early Activation and Proliferation of T Cells in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
Sopper, S., Sauer, U., Müller, J. G., Stahl‐Hennig, C., & ter Meulen, V. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/088922200308918 · Cited by 22
Therapeutic vaccines in HIV. 1 infection
Gotch, F. M., Hardy, G. A. D., & Imami, N. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01337.x · Cited by 22
Replikative Seneszenz als Alternsmodell: Die Rolle von oxidativem Streß und Telomerenverkürzung - eine übersicht
Saretzki, G. C., & von Zglinicki, T. (1999) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910050086 · Cited by 20
Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults
Rodríguez-Centeno, J., Esteban-Cantos, A., Montejano, R., Stella-Ascariz, N., Buckley, R. D. M., Mena-Garay, B., Saiz-Medrano, G., Alejos, B., Jiménez-González, M., Bernardino, J. I., et al. (2021) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkab492 · Cited by 19
Determinants of blood telomere length in antiretroviral treatment‐naïve HIV ‐positive participants enrolled in the NEAT 001/ ANRS 143 clinical trial
Alejos, B., Stella-Ascariz, N., Montejano, R., Rodríguez-Centeno, J., Schwimmer, C., Bernardino, J. I., Rodés, B., Esser, S., Goujard, C., Sarmento‐Castro, R., et al. (2019) · HIV Medicine · doi:10.1111/hiv.12791 · Cited by 19
HIV, Cytokines and Programmed Cell Death: A Subtle Interplay
Gougeon, M., Ledru, É., Naora, H., Bocchino, M., & LECOEUR, H. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05596.x · Cited by 19
The Cell Biology of Stem Cells
Meshorer, E., & Plath, K. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7037-4 · Cited by 20
The HIV infection and immune activation: ‘To fight and burn’
Appay, V., Boutboul, F., & Autran, B. (2005) · Current Infectious Disease Reports · doi:10.1007/s11908-005-0050-9 · Cited by 18
Interpreting Data on Lymphocyte Subsets in the Blood of HIV Patients – Organ Distribution, Proliferation and Migration Kinetics Are Critical Factors
Pabst, R., & Rosenberg, Y. J. (1998) · Pathobiology · doi:10.1159/000028006 · Cited by 18
Telomerase targeting in cancer treatment: new developments
Helder, M. N., de Jong, S., de Vries, E. G. E., & van der Zee, A. G. J. (1999) · Drug Resistance Updates · doi:10.1054/drup.1999.0074 · Cited by 18
Long-Term Telomere Dynamics: Modest Increase of Cell Turnover in HIV-Infected Individuals Followed for up to 14 Years
Feng, Y., Biggar, R. J., Gee, D., Norwood, D., Zeichner, S. L., & Dimitrov, D. S. (1999) · Pathobiology · doi:10.1159/000028048 · Cited by 17
Asymptomatic Simian Immunodeficiency Virus Infection Decreases Blood CD4+T Cells by Accumulating Recirculating Lymphocytes in the Lymphoid Tissues
Schenkel, A. R., Uno, H., & Pauza, C. D. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.601-607.1999 · Cited by 17
Immune reconstitution in HIV infection
Autran, B. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7869-2_9 · Cited by 17
Early increase of CD4+ CD45RA+ and CD4+ CD95− cells with conserved repertoire induced by anti-retroviral therapy in HIV-infected patients
Silvestri, G., Munoz-Calleja, C., Bagnarelli, P., Piedimonte, G., Clementi, M., & Montroni, M. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00464.x · Cited by 17
Biomarkers of cellular aging during a controlled human malaria infection
Miglar, A., Reuling, I. J., Yap, X. Z., Färnert, A., Sauerwein, R. W., & Asghar, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-97985-y · Cited by 17
Model of HIV-1 Disease Progression Based on Virus-Induced Lymph Node Homing and Homing-Induced Apoptosis of CD4+ Lymphocytes
Kirschner, D. E., Webb, G. F., & Cloyd, M. W. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200008010-00010 · Cited by 16
HIV-1 and its causal relationship to immunosuppression and nervous system disease in AIDS: A review
Sotrel, A. (2000) · Human Pathology · doi:10.1053/hupa.2000.19293 · Cited by 16
The Effect of Deletion of the V3 Loop of gp120 on Cytotoxic T Cell Responses and HIV gp120-Mediated Pathogenesis
Kmieciak, D., Wasik, T. J., Teppler, H., Pientka, J., Hsu, S. H., Takahashi, H., Okumura, K., Kaneko, Y., & Kozbor, D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5676 · Cited by 16
Unraveling the strands of HIV's web
Pantaleo, G. (1999) · Nature Medicine · doi:10.1038/4706 · Cited by 16
Preferential S Phase Entry and Apoptosis of CD4+ T Lymphocytes of HIV-1-Infected Patients after in Vitro Cultivation
Patki, A. H., Zielske, S. P., Sieg, S. F., & Lederman, M. M. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4940 · Cited by 16
The potential importance of HIV-induction of lymphocyte homing to lymph nodes
Chen, J. J.-Y., & Cloyd, M. W. (1999) · International Immunology · doi:10.1093/intimm/11.10.1591 · Cited by 16
T Cell Apoptosis in HIV Infection: Mechanisms and Relevance for AIDS Pathogenesis
Gougeon, M., Ledru, É., Lecoeur, H., & Garcia, S. (1998) · Results and problems in cell differentiation · doi:10.1007/978-3-540-69185-3_11 · Cited by 16
Estimation of the Amount of Telomere Molecules in Different Human Age Groups and the Telomere Increasing Effect of Acupuncture and Shiatsu on St.36, Using Synthesized Basic Units of the Human Telomere Molecules as Reference Control Substances for the Bi-Digital O-Ring Test Resonance Phenomenon
Omura, Y., Shimotsura, Y., Ooki, M., & Noguchi, T. (1998) · Acupuncture & Electro-Therapeutics Research · doi:10.3727/036012998816356472 · Cited by 15
Apoptosis in T-Lymphocyte Subsets in Human Immunodeficiency Virus-Infected Children Measured Immediately Ex Vivo and following In Vitro Activation
Niehues, T., McCloskey, T. W., Ndagijimana, J., Horneff, G., Wahn, V., & Pahwa, S. G. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.1.74-78.2001 · Cited by 15
Telomere Length Declines in Persons With Human Immunodeficiency Virus Before Antiretroviral Therapy Start but Not After Viral Suppression: A Longitudinal Study Over >17 Years
Schoepf, I. C., Thorball, C. W., Ledergerber, B., Kootstra, N. A., Reiss, P., Raffenberg, M., Engel, T., Braun, D. L., Hasse, B. K., Thurnheer, C., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab603 · Cited by 14
Human Immunodeficiency Virus Pathogenesis: Insights from Studies of Lymphoid Cells and Tissues
Kilby, J. M. (2001) · Clinical Infectious Diseases · doi:10.1086/322647 · Cited by 14
Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells
Scheuring, U. J., Sabzevari, H., Corbeil, J., & Theofilopoulos, A. N. (1999) · AIDS · doi:10.1097/00002030-199902040-00004 · Cited by 14
T‐cell telomere length maintained in HIV‐infected long‐term survivors
Tucker, V. C., Jenkins, J., Gilmour, J. W., Savoie, H., Easterbrook, P., Gotch, F., & Browning, M. J. (2000) · HIV Medicine · doi:10.1046/j.1468-1293.2000.00010.x · Cited by 14
Subcutaneous Interleukin-2 in Combination with Anti-retroviral Therapy for Treatment of HIV-1-Infected Subjects
Larsen, C. S. (2000) · Scandinavian Journal of Infectious Diseases · doi:10.1080/003655400750045259 · Cited by 14
Suppression of Intracellular Hydrogen Peroxide Generation and Catalase Levels in CD8+ T-Lymphocytes From HIV+ Individuals
Yano, S., Yano, N., Rodríguez, N., Baek, J. H., Que, X., Yamamura, Y., & Kim, S. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00275-x · Cited by 13

Authors: Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., Meyaard, L., & Miedema, F.
Affiliations: University of Amsterdam (NL)
University Medical Center Groningen (NL)
K. C. Wolthers, S. A. Otto, A.-M. de Roda Husman, N. Schaft, L. Meyaard, Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, Netherlands.
F. de Wolf and J. Goudsmit, Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Amsterdam UMC Location University of Amsterdam (NL)
GGD Amsterdam (NL)
G. B. A. Wisman and A. G. J. van der Zee, Department of Gynaecology and Obstetrics, Academic Hospital Groningen, University of Groningen, Groningen, Netherlands.
Corresponding author: Miedema, Frank
ORCID: Wolthers, Katja C.
Schaft, Niels
Meyaard, Linde
Miedema, Frank
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-11-29
Volume: 274
Issue: 5292
Pages: 1543-1547
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.274.5292.1543
OpenAlex: W2055875053
Cited by: 286
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 5
FWCI: 8.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: HIV-1 infection, telomere length, terminal restriction fragments, CD4+ T cells, CD8+ T cells, T cell turnover, telomerase activity, immunosenescence, AIDS progression
MeSH terms: Acquired Immunodeficiency Syndrome, Cell Division, Cross-Sectional Studies, Humans, Leukocytes, Mononuclear, Male, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Matched-Pair Analysis, Telomere, Cell Death, CD8-Positive T-Lymphocytes, Disease Progression, Lymphocyte Count, CD4 Lymphocyte Count, Telomerase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks