CoChat
Sign Up
Cited by 287HIV Research and TreatmentTelomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover

Wolthers, Katja C., Bea, G., Wisman, A., Otto, Sigrid A., de Roda Husman, Ana-Maria, Schaft, Niels, de Wolf, Frank, Goudsmit, Jaap, Coutinho, Roel A., van der Zee, Ate G. J., Meyaard, Linde, Miedema, Frank·1996·Science
DOI 10.1126/science.274.5292.1543
Open this paper in CoChat — free account

Abstract

Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8 + T cell TRF length decreased but CD4 + T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8 + T cells, but not in CD4 + T cells. These results are compatible with CD4 + T cell decline in HIV-1 infection caused by interference with cell renewal.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.274.5292.1543

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 58 references

Research works printed but not linked: 7

  1. Bofill M., et al., ibid. 10, 827 (1996).
  2. Gougeon M., Montagnier L., ibid. 260, 1269 (1993);
  3. Muro-Cacho C. A., Pantaleo G., Fauci A. S., ibid. 154, 5555 (1995).
  4. Morin G. B., ibid. 59, 521 (1989);
  5. Vaziri H., et al., Am. J. Hum. Genet. 52, 661 (1993).
  6. Slagboom P. E., Droog S., Boomsma D. I., Am. J. Hum. Genet. 55, 876 (1994).
  7. De Lange T., et al., Mol. Cell. Biol. 10, 518 (1990).

Cited by

Sorted by citations

Items 201–287 of 287

Related

See all

Metadata

Authors
Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., Meyaard, L., & Miedema, F.
Affiliations
  • University of Amsterdam (NL)
  • University Medical Center Groningen (NL)
  • K. C. Wolthers, S. A. Otto, A.-M. de Roda Husman, N. Schaft, L. Meyaard, Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, Netherlands.
  • F. de Wolf and J. Goudsmit, Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
  • Amsterdam UMC Location University of Amsterdam (NL)
  • GGD Amsterdam (NL)
  • G. B. A. Wisman and A. G. J. van der Zee, Department of Gynaecology and Obstetrics, Academic Hospital Groningen, University of Groningen, Groningen, Netherlands.
Corresponding author
Miedema, Frank
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-11-29
Volume
274
Issue
5292
Pages
1543-1547
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.274.5292.1543
OpenAlex
W2055875053
Cited by
286
References
58
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 5
FWCI
8.82
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
HIV-1 infection, telomere length, terminal restriction fragments, CD4+ T cells, CD8+ T cells, T cell turnover, telomerase activity, immunosenescence, AIDS progression
MeSH terms
Acquired Immunodeficiency Syndrome, Cell Division, Cross-Sectional Studies, Humans, Leukocytes, Mononuclear, Male, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Matched-Pair Analysis, Telomere, Cell Death, CD8-Positive T-Lymphocytes, Disease Progression, Lymphocyte Count, CD4 Lymphocyte Count, Telomerase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review