The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation
Abstract
Overexpression of the familial Alzheimer's disease gene Presenilin 2 ( PS2 ) in nerve growth factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or β-amyloid. Transfection of antisense PS2 conferred protection against apoptosis induced by trophic withdrawal in nerve growth factor-differentiated or amyloid precursor protein-expressing PC12 cells. The apoptotic cell death induced by PS2 protein was sensitive to pertussis toxin, suggesting that heterotrimeric GTP-binding proteins are involved. A PS2 mutation associated with familial Alzheimer's disease was found to generate a molecule with enhanced basal apoptotic activity. This gain of function might accelerate the process of neurodegeneration that occurs in Alzheimer's disease, leading to the earlier age of onset characteristic of familial Alzheimer's disease.
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Self-citationCandidate gene for the chromosome 1 familial Alzheimer’s disease locus
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Cited by
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370
Translating cell biology into therapeutic advances in Alzheimer's disease
Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,166
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
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Oxidative stress in Alzheimer’s disease
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00040-5 · Cited by 895
Metadata
- Authors
- Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J. K., Lacanà, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., & D'Adamio, L.
- Venue
- Science
- Published
- 1996-12-06
- Volume
- 274
- Issue
- 5293
- Pages
- 1710-1713
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025242397
- Cited by
- 423
- References
- 7
- FWCI
- 34.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation. https://app.cochat.ai/papers/10.1126/science.274.5293.1710
- The paper
- Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J. K., Lacanà, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., & D'Adamio, L. (1996). Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation. Science. https://doi.org/10.1126/science.274.5293.1710
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
