The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator
Abstract
The nuclear factor κB (NF-κB) transcription factor is responsive to specific cytokines and stress and is often activated in association with cell damage and growth arrest in eukaryotes. NF-κB is a heterodimeric protein, typically composed of 50- and 65-kilodalton subunits of the Rel family, of which RelA(p65) stimulates transcription of diverse genes. Specific cyclin-dependent kinases (CDKs) were found to regulate transcriptional activation by NF-κB through interactions with the coactivator p300. The transcriptional activation domain of RelA(p65) interacted with an amino-terminal region of p300 distinct from a carboxyl-terminal region of p300 required for binding to the cyclin E-Cdk2 complex. The CDK inhibitor p21 or a dominant negative Cdk2, which inhibited p300-associated cyclin E-Cdk2 activity, stimulated κB-dependent gene expression, which was also enhanced by expression of p300 in the presence of p21. The interaction of NF-κB and CDKs through the p300 and CBP coactivators provides a mechanism for the coordination of transcriptional activation with cell cycle progression.
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Cites
WAF1, a potential mediator of p53 tumor suppression
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
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Self-citationp21 is a universal inhibitor of cyclin kinases
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Self-citationWAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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Structure, Regulation and Function of NF-kappaB
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An inducible transcription factor activates expression of human immunodeficiency virus in T cells
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Self-citationInducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
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Cited by
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5785 · Cited by 1,312
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Chan, H. M., & La Thangue, N. B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2363 · Cited by 1,092
Metadata
- Authors
- Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D. H., & Nabel, G. J.
- Venue
- Science
- Published
- 1997-01-24
- Volume
- 275
- Issue
- 5299
- Pages
- 523-527
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086008721
- Cited by
- 722
- References
- 46
- FWCI
- 32.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D. H., & Nabel, G. J. (1997). Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator. Science. https://doi.org/10.1126/science.275.5299.523
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
