Phylogenetic Methods Come of Age: Testing Hypotheses in an Evolutionary Context
Abstract
The use of molecular phylogenies to examine evolutionary questions has become commonplace with the automation of DNA sequencing and the availability of efficient computer programs to perform phylogenetic analyses. The application of computer simulation and likelihood ratio tests to evolutionary hypotheses represents a recent methodological development in this field. Likelihood ratio tests have enabled biologists to address many questions in evolutionary biology that have been difficult to resolve in the past, such as whether host-parasite systems are cospeciating and whether models of DNA substitution adequately explain observed sequences.
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Statistical tests for rate changes along a phylogeny have been a part of phylogenetic methodology for several decades and are closely tied to tests for a molecular clock.
“Statistical tests for rate changes along a phylogeny have been a part of phylogenetic methodology for several decades, and are closely tied to tests for a molecular clock”
From Bayesian Detection of Convergent Rate Changes of Conserved Noncoding Elements on Phylogenetic Trees (2019) · cites this paper as Huelsenbeck and Rannala 1997
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Bayesian Detection of Convergent Rate Changes of Conserved Noncoding Elements on Phylogenetic Trees
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- Authors
- Huelsenbeck, J. P., & Rannala, B.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Huelsenbeck, John P.
- Venue
- Science
- Published
- 1997-04-11
- Volume
- 276
- Issue
- 5310
- Pages
- 227-232
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068117230
- Cited by
- 781
- References
- 5
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 21 · 2019: 12 · 2018: 8 · 2017: 16 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 14 · 2012: 23
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-40282, R01GM040282)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Keywords
- phylogenetic hypothesis testing, likelihood ratio test, computer simulation, molecular phylogeny, host-parasite coevolution, cospeciation, evolutionary hypothesis testing
- MeSH terms
- Animals, Base Sequence, Computer Simulation, Electron Transport Complex IV, DNA, Biological Evolution, Orthohantavirus, Phthiraptera, Mutation, Phylogeny, RNA, Viral, Rodentia, Likelihood Functions, Evolution, Molecular
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