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Kinetics of Response in Lymphoid Tissues to Antiretroviral Therapy of HIV-1 Infection
Open accessAbstract
In lymphoid tissue, where human immunodeficiency virus–type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden. This was shown by in situ hybridization and computerized quantitative analysis of serial tonsil biopsies from previously untreated adults. The frequency of productive mononuclear cells (MNCs) initially diminished with a half-life of about 1 day. Surprisingly, the amount of HIV-1 RNA in virus trapped on follicular dendritic cells (FDCs) decreased almost as quickly. After 24 weeks, MNCs with very few copies of HIV-1 RNA per cell were still detectable, as was proviral DNA; however, the amount of FDC-associated virus decreased by ≥3.4 log units. Thus, 6 months of potent therapy controlled active replication and cleared >99.9 percent of virus from the secondary lymphoid tissue reservoir.
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Cited by
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., et al. (1997) · Science · doi:10.1126/science.278.5341.1295 · Cited by 3,098
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells
Zhang, Z.-Q., Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., et al. (1999) · Science · doi:10.1126/science.286.5443.1353 · Cited by 874
Self-citationPitcher, C. J., Quittner, C., Peterson, D. M., Connors, M., Koup, R. A., Maino, V. C., & Picker, L. J. (1999) · Nature Medicine · doi:10.1038/8400 · Cited by 746
Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Pöppelmann, B., Luger, T. A., & Schwarz, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.1.171 · Cited by 463
Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
Pope, M., & Haase, A. T. (2003) · Nature Medicine · doi:10.1038/nm0703-847 · Cited by 355
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Metadata
- Authors
- Cavert, W., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, M., Gebhard, K., Henry, K., Zhang, Z.-Q., Mills, R., McDade, H., Goudsmit, J., Danner, S. A., & Haase, A. T.
- Venue
- Science
- Published
- 1997-05-09
- Volume
- 276
- Issue
- 5314
- Pages
- 960-964
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2114654929
- Cited by
- 622
- References
- 0
- FWCI
- 26.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Cavert, W., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, M., Gebhard, K., Henry, K., Zhang, Z.-Q., Mills, R., McDade, H., Goudsmit, J., Danner, S. A., & Haase, A. T. (1997). Kinetics of Response in Lymphoid Tissues to Antiretroviral Therapy of HIV-1 Infection. Science. https://doi.org/10.1126/science.276.5314.960
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