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Lamina-Specific Connectivity in the Brain: Regulation by N-Cadherin, Neurotrophins, and Glycoconjugates

Inoue, Akihiro, Sanes, Joshua R.·1997·Science

Abstract

In the vertebrate brain, neurons grouped in parallel laminae receive distinct sets of synaptic inputs. In the avian optic tectum, arbors and synapses of most retinal axons are confined to 3 of 15 laminae. The adhesion molecule N-cadherin and cell surface glycoconjugates recognized by a plant lectin are selectively associated with these “retinorecipient” laminae. The lectin and a monoclonal antibody to N-cadherin perturbed laminar selectivity in distinct fashions. In contrast, neurotrophins increased the complexity of retinal arbors without affecting their laminar distribution. Thus, cell surface molecules and soluble trophic factors may collaborate to shape lamina-specific arbors in the brain, with the former predominantly affecting their position and the latter their size.

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Metadata

Authors
Inoue, A., & Sanes, J. R.
Venue
Science
Published
1997-05-30
Volume
276
Issue
5317
Pages
1428-1431
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2006913118
Cited by
387
References
1
FWCI
9.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Lamina-Specific Connectivity in the Brain: Regulation by N-Cadherin, Neurotrophins, and Glycoconjugates. https://app.cochat.ai/papers/10.1126/science.276.5317.1428
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Inoue, A., & Sanes, J. R. (1997). Lamina-Specific Connectivity in the Brain: Regulation by N-Cadherin, Neurotrophins, and Glycoconjugates. Science. https://doi.org/10.1126/science.276.5317.1428

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