The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization
Abstract
Retinal neovascularization is the major cause of untreatable blindness. The role of growth hormone (GH) in ischemia-associated retinal neovascularization was studied in transgenic mice expressing a GH antagonist gene and in normal mice given an inhibitor of GH secretion (MK678). Retinal neovascularization was inhibited in these mice in inverse proportion to serum levels of GH and a downstream effector, insulin-like growth factor–I (IGF-I). Inhibition was reversed with exogenous IGF-I administration. GH inhibition did not diminish hypoxia-stimulated retinal vascular endothelial growth factor (VEGF) or VEGF receptor expression. These data suggest that systemic inhibition of GH or IGF-I, or both, may have therapeutic potential in preventing some forms of retinopathy.
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Self-citationEarly Photocoagulation for Diabetic Retinopathy
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Self-citationPhotocoagulation Treatment of Proliferative Diabetic Retinopathy
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Vascular endothelial growth factor
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Insulin-like Growth Factors: Studies in Diabetics with and without Retinopathy
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Hellström, A., Smith, L. E., & Dammann, O. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60178-6 · Cited by 1,304
Self-citationClinical applications of angiogenic growth factors and their inhibitors
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The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina
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Metadata
- Authors
- Smith, L. E. H., Kopchick, J. J., Chen, W., Knapp, J., Kinose, F., Daley, D., Foley, E., Smith, R. G., & Schaeffer, J. M.
- Venue
- Science
- Published
- 1997-06-13
- Volume
- 276
- Issue
- 5319
- Pages
- 1706-1709
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055696255
- Cited by
- 393
- References
- 23
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, L. E. H., Kopchick, J. J., Chen, W., Knapp, J., Kinose, F., Daley, D., Foley, E., Smith, R. G., & Schaeffer, J. M. (1997). Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization. Science. https://doi.org/10.1126/science.276.5319.1706
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
