Cited by 499Cannabis and Cannabinoid ResearchStress Responses and CortisolNeuropeptides and Animal Physiology

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Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

Rodrı́guez de Fonseca, Fernando, Carrera, M. Rocı́o A., Navarro, Miguel, Koob, George F., Weiss, Friedbert·1997·Science

DOI 10.1126/science.276.5321.2050

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Abstract

Corticotropin-releasing factor (CRF) has been implicated in the mediation of the stress-like and negative affective consequences of withdrawal from drugs of abuse, such as alcohol, cocaine, and opiates. This study sought to determine whether brain CRF systems also have a role in cannabinoid dependence. Rats were treated daily for 2 weeks with the potent synthetic cannabinoid HU-210. Withdrawal, induced by the cannabinoid antagonist SR 141716A, was accompanied by a marked elevation in extracellular CRF concentration and a distinct pattern of Fos activation in the central nucleus of the amygdala. Maximal increases in CRF corresponded to the time when behavioral signs resulting from cannabinoid withdrawal were at a maximum. These data suggest that long-term cannabinoid administration alters CRF function in the limbic system of the brain, in a manner similar to that observed with other drugs of abuse, and also induces neuroadaptive processes that may result in future vulnerability to drug dependence.

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey
Anthony, J. C., Warner, L. A., & Kessler, R. C. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.3.244 · Cited by 1,341
Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat
Bullitt, E. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960402 · Cited by 1,059
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608

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Hollister L., Pharmacol. Rev. 38, 1 (1986).
Fishman M. W., Rosenbaum J. F., Jabusaka D. I., Carr D. B., Res. Commun. Subst. Abuse 9, 219 (1988) ;
Pope H. G., Yurgelun-Todd D., JAMA 275, 521 (1996). · DOI
Kaymakcalan S., Bull. Narc. 25, 39 (1973);
Devane W. A., Dysarz F. A., Johnson M. R., Melvin L. S., Howlett A., Mol. Pharmacol. 34, 605 (1988);
de Fonseca F. R., et al., J. Pharmacol. Exp. Ther. 276, 56 (1996).
Koob G. F., Bloom F. E., Fed. Proc. 44, 259 (1985);
Richter R. M., Merlo Pich E., Koob G. F., Weiss F., ibid. 187, 169 (1995).
Pfahl M., Endocr. Rev. 14, 651 (1993).
Stornetta R. L., Norton F. E., Guyenet P. G., ibid. 624, 19 (1993);

Sorted by citations

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Self-citation
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Self-citation
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Drug Addiction
Justinová, Z., Panlilio, L. V., & Goldberg, S. R. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_13 · Cited by 40
Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice
Trexler, K. R., Nass, S. R., Crowe, M. S., Gross, J., Jones, M. S., McKitrick, A. W., Siderovski, D. P., & Kinsey, S. G. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.05.029 · Cited by 38
Endocannabinoid lipids and mediated system: Implications for alcoholism and neuropsychiatric disorders
Vinod, K. Y., & Hungund, B. L. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.041 · Cited by 38
Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice
Oliva, J. M., Ortiz, S., Palomo, T., & Manzanares, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01627.x · Cited by 37
Corticotropin-Releasing Hormone (CRH) mRNA Expression in Rat Central Amygdala in Cannabinoid Tolerance and Withdrawal: Evidence for an Allostatic Shift?
Caberlotto, L., Rimondini, R., Hansson, A. C., Eriksson, S., & Heilig, M. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300296 · Cited by 37
Marijuana Dependence: Not Just Smoke and Mirrors
Ramesh, D., Schlosburg, J. E., Wiebelhaus, J. M., & Lichtman, A. H. (2011) · ILAR Journal · doi:10.1093/ilar.52.3.295 · Cited by 39
The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
Skelton, K. H., Oren, D., Gutman, D. A., Easterling, K. W., Holtzman, S. G., Nemeroff, C. B., & Owens, M. J. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.041 · Cited by 36
The psychoactive ingredient of marijuana induces behavioural sensitization
Rubino, T., Viganò, D., Massi, P., & Parolaro, D. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01709.x · Cited by 36
Effect of drugs of abuse on social behaviour
Blanco-Gandía, M. C., Mateos-García, A., García-Pardo, M. P., Montagud‐Romero, S., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000162 · Cited by 38
Recent Research on Alcohol Tolerance and Dependence
Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. B., Li, T., & Weiss, F. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105051-00031 · Cited by 35
Self-citation
The effect of exposure to drugs on the processing of natural rewards
Anselme, P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.002 · Cited by 35
Substance abuse disorders
Reid, A. G., Lingford-Hughes, A. R., Cancela, L. M., & Kalivas, P. W. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00024-3 · Cited by 35
Metabolic Mapping of the Effects of Win 55212–2 Intravenous Administration in the Rat
Pontieri, F. E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00064-0 · Cited by 35
Parent and peer influences on emerging adult substance use disorder: A genetically informed study
Bountress, K. E., Chassin, L., & Lemery‐Chalfant, K. (2016) · Development and Psychopathology · doi:10.1017/s095457941500125x · Cited by 32
Greater delay discounting and cannabis coping motives are associated with more frequent cannabis use in a large sample of adult cannabis users
Sofis, M. J., Budney, A. J., Stanger, C., Knapp, A. A., & Borodovsky, J. T. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107820 · Cited by 36
Individual Differences in Response to Stress and Risk for Addiction
Lovallo, W. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012370632-4/50014-0 · Cited by 33
Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake
Anghel, A., Jamieson, C. A. M., Ren, X., Young, J., Porche, R., Ozigbo, E., Ghods, D. E., Lee, M. L., Liu, Y., Lutfy, K., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.043 · Cited by 34
Cannabinoids modulate ultrasound-induced aversive responses in rats
Finn, D. P., Jhaveri, M. D., Beckett, S. R. G., Kendall, D. A., Marsden, C. A., & Chapman, V. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1629-1 · Cited by 32
Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation
Tallett, A. J., Blundell, J. E., & Rodgers, J. R. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282eff0a9 · Cited by 32
Pimecrolimus cream 1% can be an effective treatment for seborrheic dermatitis of the face and trunk.
Rallis, E. A., Nasiopoulou, A., KOUSKOUKIS, C. E., & Koumantaki, E. (2004) · PubMed · Cited by 32
Behavioral sensitization to WIN55212.2 in rats pretreated with heroin
Pontieri, F. E., Monnazzi, P., Scontrini, A., Buttarelli, F. R., & Patacchioli, F. R. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02158-8 · Cited by 32
Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice
Aracil-Fernández, A., Almela, P., & Manzanares, J. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00406.x · Cited by 31
Role of different brain structures in the behavioural expression of WIN 55,212‐2 withdrawal in mice
Castañé, A., Maldonado, R. J., & Valverde, O. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705882 · Cited by 31
Substance abuse and addiction--the need to know.
Califano, J. A. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.1.9 · Cited by 31
Drug abuse-associated mortality across the lifespan: a population-based longitudinal cohort and co-relative analysis
Kendler, K. S., Ohlsson, H., Sundquist, K., & Sundquist, J. (2017) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-017-1398-5 · Cited by 28

Authors: Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F.
Affiliations: F. Rodrı́guez de Fonseca and M. Navarro, Instituto Complutense de Drogodependencias, Departamento de Psicobiologı́a, Facultad de Psicologı́a, Universidad Complutense de Madrid, 28223 Madrid, Spain.
Universidad Complutense de Madrid (ES)
Corresponding author: Navarro, Miguel
ORCID: Navarro, Miguel
Koob, George F.
Weiss, Friedbert
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-06-27
Volume: 276
Issue: 5321
Pages: 2050-2054
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.276.5321.2050
OpenAlex: W2124997151
Cited by: 499
References: 45
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 11 · 2018: 19 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 21
FWCI: 27.34
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r03da008426-02)
National Institute on Drug Abuse (DA 08426)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: corticotropin-releasing factor, cannabinoid withdrawal, HU-210, SR141716A, Fos activation, central amygdala, limbic system, neural adaptation, drug addiction, stress response
MeSH terms: Rimonabant, Amygdala, Animals, Anxiety, Behavior, Animal, Brain, Corticosterone, Corticotropin-Releasing Hormone, Male, Piperidines, Pyrazoles, Receptors, Drug, Substance Withdrawal Syndrome, Dronabinol, Proto-Oncogene Proteins c-fos, Rats, Wistar, Microdialysis, Receptors, Cannabinoid, Rats

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Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

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