Cited by 499Cannabis and Cannabinoid ResearchStress Responses and CortisolNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

Rodrı́guez de Fonseca, Fernando, Carrera, M. Rocı́o A., Navarro, Miguel, Koob, George F., Weiss, Friedbert·1997·Science

DOI 10.1126/science.276.5321.2050

Open this paper in CoChat — free account

Abstract

Corticotropin-releasing factor (CRF) has been implicated in the mediation of the stress-like and negative affective consequences of withdrawal from drugs of abuse, such as alcohol, cocaine, and opiates. This study sought to determine whether brain CRF systems also have a role in cannabinoid dependence. Rats were treated daily for 2 weeks with the potent synthetic cannabinoid HU-210. Withdrawal, induced by the cannabinoid antagonist SR 141716A, was accompanied by a marked elevation in extracellular CRF concentration and a distinct pattern of Fos activation in the central nucleus of the amygdala. Maximal increases in CRF corresponded to the time when behavioral signs resulting from cannabinoid withdrawal were at a maximum. These data suggest that long-term cannabinoid administration alters CRF function in the limbic system of the brain, in a manner similar to that observed with other drugs of abuse, and also induces neuroadaptive processes that may result in future vulnerability to drug dependence.

Integrity signals

Registry

Crossref · 10.1126/science.276.5321.2050

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey
Anthony, J. C., Warner, L. A., & Kessler, R. C. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.3.244 · Cited by 1,341
Expression of C‐fos‐like protein as a marker for neuronal activity following noxious stimulation in the rat
Bullitt, E. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960402 · Cited by 1,059
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608

Flagged first, then by citations

Show all 45 references

1 of the 45 references couldn’t be matched to a known paper.

Research works printed but not linked: 10

Hollister L., Pharmacol. Rev. 38, 1 (1986).
Fishman M. W., Rosenbaum J. F., Jabusaka D. I., Carr D. B., Res. Commun. Subst. Abuse 9, 219 (1988) ;
Pope H. G., Yurgelun-Todd D., JAMA 275, 521 (1996). · DOI
Kaymakcalan S., Bull. Narc. 25, 39 (1973);
Devane W. A., Dysarz F. A., Johnson M. R., Melvin L. S., Howlett A., Mol. Pharmacol. 34, 605 (1988);
de Fonseca F. R., et al., J. Pharmacol. Exp. Ther. 276, 56 (1996).
Koob G. F., Bloom F. E., Fed. Proc. 44, 259 (1985);
Richter R. M., Merlo Pich E., Koob G. F., Weiss F., ibid. 187, 169 (1995).
Pfahl M., Endocr. Rev. 14, 651 (1993).
Stornetta R. L., Norton F. E., Guyenet P. G., ibid. 624, 19 (1993);

Sorted by citations

Items 101–200 of 498

Identification of a high-affinity binding site involved in the transport of endocannabinoids
Moore, S. A., Nomikos, G. G., Chesterfield, A. K., Schober, D. A., Schaus, J. M., Ying, B.-P., Xu, Y., Phebus, L. A., Simmons, R. M. A., Li, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507470102 · Cited by 166
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
Nogueiras, R., Veyrat‐Durebex, C., Suchanek, P. M., Klein, M., Tschöp, J., Caldwell, C. C., Woods, S. C., Wittmann, G., Watanabe, M., Liposits, Z., et al. (2008) · Diabetes · doi:10.2337/db08-0161 · Cited by 158
Neurobiology of dysregulated motivational systems in drug addiction
Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157
Self-citation
Development of pharmacotherapies for drug addiction: a Rosetta stone approach
Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154
Self-citation
Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor.
Cooper, Z. D., & Haney, M. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00095.x · Cited by 158
Cannabis and endogenous cannabinoid systems
Childers, S. R., & Breivogel, C. S. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00075-1 · Cited by 157
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice.
Lichtman, A. H., Sheikh, S. M., Loh, H. H., & Martin, B. R. (2001) · PubMed · Cited by 156
Role of cannabis and endocannabinoids in the genesis of schizophrenia
Fernández‐Espejo, E., Viveros, M., Núñez, L., Ellenbroek, B. A., & de Fonseca, F. R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1612-6 · Cited by 155
Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse
Knapska, E., Radwańska, K., Werka, T., & Kaczmarek, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00037.2006 · Cited by 161
Reward Inhibits Paraventricular CRH Neurons to Relieve Stress
Yuan, Y., Wu, W., Chen, M., Cai, F., Fan, C., Shen, W., Sun, W., & Hu, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.048 · Cited by 151
Memory systems and the addicted brain
Goodman, J., & Packard, M. G. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00024 · Cited by 140
Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats
Trezza, V., Campolongo, P., Cassano, T., Macheda, T., Dipasquale, P., Carratù, M. R., Gaetani, S., & Cuomo, V. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1162-3 · Cited by 142
Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
Zimmer, A., Valjent, E., König, M., Zimmer, A. M., Robledo, P., Hahn, H., Valverde, O., & Maldonado, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09499.2001 · Cited by 141
Early maternal deprivation induces gender‐dependent changes on the expression of hippocampal CB1 and CB2 cannabinoid receptors of neonatal rats
Suárez, J., Llorente, R., Romero‐Zerbo, S., Mateos, B., Bermúdez‐Silva, F. J., de Fonseca, F. R., & Viveros, M. (2008) · Hippocampus · doi:10.1002/hipo.20537 · Cited by 142
Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal
McNally, G. P., & Akil, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00105-7 · Cited by 141
Cannabinoid Tolerance and Dependence
Lichtman, A. H., & Martin, B. R. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_24 · Cited by 145
Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding
Freedland, C. S., Poston, J. S., & Porrino, L. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00359-2 · Cited by 141
Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
Stinus, L., Cador, M., Zorrilla, E. P., & Koob, G. F. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300487 · Cited by 139
Self-citation
From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis
Mechoulam, R., & Ben‐Shabat, S. (1999) · Natural Product Reports · doi:10.1039/a703973e · Cited by 145
Endocannabinoids in cognition and dependence
Lichtman, A. H., Varvel, S. A., & Martin, B. R. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0351 · Cited by 135
Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.
Koob, G. F., & Zorrilla, E. P. (2010) · PubMed · Cited by 139
Self-citation
Addictive potential of cannabinoids: the underlying neurobiology
Gardner, E. L. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00162-7 · Cited by 140
Self-administration of cannabinoids by experimental animals and human marijuana smokers
Justinová, Z., Goldberg, S. R., Heishman, S. J., & Tanda, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.026 · Cited by 137
Bupropion SR worsens mood during marijuana withdrawal in humans
Haney, M., Ward, A. S., Comer, S. D., Hart, C. L., Foltin, R. W., & Fischman, M. W. (2001) · Psychopharmacology · doi:10.1007/s002130000657 · Cited by 135
Chronic (−)-Δ9-tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in rats
Gorriti, M. Á., de Fonseca, F. R., Navarro, M., & Palomo, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00851-6 · Cited by 137
Self-citation
Study of cannabinoid dependence in animals
Maldonado, R. J. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00254-1 · Cited by 136
Cannabis withdrawal in adolescent treatment seekers
Vandrey, R. G., Budney, A. J., Kamon, J. L., & Stanger, C. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.001 · Cited by 133
Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain Reward Function and Stress-Induced Relapse
Bruijnzeel, A. W., Prado, M., & Isaac, S. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.010 · Cited by 132
Role of the endocannabinoid system in depression and suicide
Vinod, K. Y., & Hungund, B. L. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.08.006 · Cited by 132
Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents
Campolongo, P., Trezza, V., Ratano, P., Palmery, M., & Cuomo, V. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1892-x · Cited by 133
Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal
Diana, M., Muntoni, A. L., Pistis, M., Melis, M., & Gessa, G. L. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00488.x · Cited by 132
Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders
Consroe, P. F. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0220 · Cited by 133
CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats
Specio, S. E., Wee, S., O’Dell, L. E., Boutrel, B., Zorrilla, E. P., & Koob, G. F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0983-9 · Cited by 132
Self-citation
Molecular and genetic substrates linking stress and addiction
Briand, L. A., & Blendy, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.002 · Cited by 125
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence
Bruijnzeel, A. W., & Gold, M. S. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.007 · Cited by 129
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Fadda, P., Robinson, L., Fratta, W., Pertwee, R., & Riedel, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.08.009 · Cited by 122
Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala
Cook, C. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.06.013 · Cited by 123
Advances in the field of cannabinoid–opioid cross‐talk
Robledo, P., Berrendero, F., Ozaita, A., & Maldonado, R. J. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00107.x · Cited by 121
Mitigation of post‐traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
Passie, T., Emrich, H. M., Karst, M., Brandt, S. D., & Halpern, J. H. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1377 · Cited by 117
The enzymatic inactivation of the fatty acid amide class of signaling lipids
Cravatt, B. F., & Lichtman, A. H. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00147-0 · Cited by 118
Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., & Weiss, F. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.027 · Cited by 112
Self-citation
Hedonic homeostatic dysregulation as a driver of drug-seeking behavior
Koob, G. F. (2008) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2009.04.002 · Cited by 114
Self-citation
Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications
Leinen, Z. J., Mohan, R., Premadasa, L. S., Acharya, A., Mohan, M., & Byrareddy, S. N. (2023) · Biomedicines · doi:10.3390/biomedicines11102630 · Cited by 114
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21
Pavón, F. J., Bilbao, A., Hernández‐Folgado, L., Cippitelli, A., Jagerovic, N., Abellán, G., Rodríguez-Franco, M. I., Serrano, A., Macías, M., de Heras, R. G., et al. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.03.029 · Cited by 115
Self-citation
Chronic treatment with Δ9-tetrahydrocannabinol enhances the locomotor response to amphetamine and heroin. Implications for vulnerability to drug addiction
Lamarque, S., Taghzouti, K., & Simon, H. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00039-9 · Cited by 114
Endocannabinoid system and opioid addiction: Behavioural aspects
Fattore, L., Deiana, S., Spano, S., Cossu, G., Fadda, P., Scherma, M., & Fratta, W. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.031 · Cited by 113
The Pharmacology of CP‐154,526, a Non‐Peptide Antagonist of the CRH1 Receptor: A Review
Seymour, P. A., Schmidt, A. W., & Schulz, D. W. (2003) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2003.tb00244.x · Cited by 111
A review of the published literature into cannabis withdrawal symptoms in human users
Smith, N. T. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00026.x · Cited by 111
Cannabinoid Withdrawal Syndrome Is Reduced in Pre-Proenkephalin Knock-Out Mice
Valverde, O., Maldonado, R. J., Valjent, E., Zimmer, A. M., & Zimmer, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09284.2000 · Cited by 110
Reduction of stress‐induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors
Valverde, O., Ledent, C. A., Beslot, F., Parmentier, M., & Roques, B. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00929.x · Cited by 112
An endocannabinoid mechanism in relapse to drug seeking: A review of animal studies and clinical perspectives
Fattore, L., Spano, M. S., Deiana, S., Melis, V., Cossu, G., Fadda, P., & Fratta, W. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.05.003 · Cited by 110
Neurochemical basis of cannabis addiction
Maldonado, R. J., Berrendero, F., Ozaita, A., & Robledo, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.035 · Cited by 113
Glucocorticoid feedback increases the sensitivity of the limbic system to stress
Cook, C. J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00650-9 · Cited by 110
Pharmacotherapy for Cannabis Dependence
Vandrey, R. G., & Haney, M. (2009) · CNS Drugs · doi:10.2165/00023210-200923070-00001 · Cited by 109
Changes in the Cannabinoid Receptor Binding, G Protein Coupling, and Cyclic AMP Cascade in the CNS of Rats Tolerant to and Dependent on the Synthetic Cannabinoid Compound CP55,940
Rubino, T., Viganò, D., Massi, P., & Parolaro, D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752080.x · Cited by 108
The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal
Contarino, A., & Papaleo, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506999102 · Cited by 107
The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users
Vandrey, R. G., Stitzer, M. L., Mintzer, M. Z., Huestis, M. A., Murray, J. A., & Lee, D. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.08.001 · Cited by 106
Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats
Bruijnzeel, A. W., Zislis, G., Wilson, C., & Gold, M. S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301192 · Cited by 107
Gabapentin for the treatment of alcohol use disorder
Mason, B. J., Quello, S., & Shadan, F. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1417383 · Cited by 104
Risky Behavior among Youths
B, J. G. A. (2001) · University of Chicago Press eBooks · doi:10.7208/chicago/9780226309972.001.0001 · Cited by 103
The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
Harrold, J. A., & Williams, G. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003942 · Cited by 100
Acute Alcohol Effects on Opiomelanocortinergic Regulation
Rasmussen, D. D., Bryant, C. A., Boldt, B. M., Colasurdo, E. A., Levin, N., & Wilkinson, C. W. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03870.x · Cited by 99
Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment
Hill, M. N., Sun, J. C., Tse, M., & Gorzalka, B. B. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005651 · Cited by 98
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-na??ve and plus-maze-experienced mice
Rodgers, R. J., Evans, P., & Murphy, A. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00013 · Cited by 101
The Association between Regular Cannabis Exposure and Alterations of Human Brain Morphology: An Updated Review of the Literature
Lorenzetti, V., Solowij, N., Fornito, A., Lubman, D. I., & Yücel, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990435 · Cited by 99
Role of Corticotropin‐Releasing Factor Receptor‐1 in Opiate Withdrawal
Iredale, P. A., Alvaro, J. D., Lee, Y., Terwilliger, R. Z., Chen, Y. L., & Duman, R. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740199.x · Cited by 96
Legalization of Marijuana: Potential Impact on Youth
Joffe, A., & Yancy, W. S. (2004) · PEDIATRICS · doi:10.1542/peds.113.6.e632 · Cited by 95
The Corticotropin-Releasing Factor (CRF)-system and monoaminergic afferents in the central amygdala: Investigations in different mouse strains and comparison with the rat
Asan, E., Yilmazer‐Hanke, D., Eliava, M., Hantsch, M., Lesch, K., & Schmitt, A. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.040 · Cited by 95
MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
RICHARDSON, H., ZHAO, Y., Fekete, É. M., FUNK, C., Wirsching, P., Janda, K. D., Zorrilla, E. P., & Koob, G. F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.008 · Cited by 95
Self-citation
Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2
Aceto, M. D. G., Scates, S. M., & Martin, B. R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00873-1 · Cited by 95
Factors associated with lapses to heroin use during methadone maintenance
Wasserman, D. A., WEINSTEIN, M. G., Havassy, B. E., & Hall, S. M. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00092-1 · Cited by 94
Attributes of long-term heavy cannabis users: a case–control study
Gruber, A. J., Pope, H. G., Hudson, J. I., & Yurgelun-Todd, D. A. (2003) · Psychological Medicine · doi:10.1017/s0033291703008560 · Cited by 94
Opioid and Cannabinoid Modulation of Precipitated Withdrawal in Δ9-Tetrahydrocannabinol and Morphine-Dependent Mice
Lichtman, A. H., Sheikh, S. M., Loh, H. H., & Martin, B. R. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29469-6 · Cited by 175
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain
Manzanares, J., Corchero, J., Romero, J., Fernández‐Ruíz, J., Ramos, J. A., & Fuentes, J. A. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00371-9 · Cited by 93
Emerging Role for Corticotropin Releasing Factor Signaling in the Bed Nucleus of the Stria Terminalis at the Intersection of Stress and Reward
Silberman, Y., & Winder, D. G. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00042 · Cited by 96
Dependence of mesolimbic dopamine transmission on Δ9-tetrahydrocannabinol
Tanda, G., Loddo, P., & Chiara, G. D. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00384-2 · Cited by 89
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence
Lü, L. T., Liu, D., Ceng, X., & Ma, L. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01310.x · Cited by 89
‘One‐trial sensitization’ to the anxiolytic‐like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus‐maze
Rodgers, R. J., Haller, J., Halász, J., & Mikics, É. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02548.x · Cited by 88
Drug addiction: Functional neurotoxicity of the brain reward systems
Weiss, F., & Koob, G. F. (2001) · Neurotoxicity Research · doi:10.1007/bf03033235 · Cited by 86
Self-citation
Corticotropin-Releasing Factor Within the Central Nucleus of the Amygdala and the Nucleus Accumbens Shell Mediates the Negative Affective State of Nicotine Withdrawal in Rats
Marcinkiewcz, C. A., Prado, M., Isaac, S. K., Marshall, S. A., Rylkova, D., & Bruijnzeel, A. W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.231 · Cited by 89
Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142
Sink, K. S., Segovia, K. N., Sink, J. R., Randall, P. A., Collins, L. E., Correa, M., Markus, E. J., Vemuri, K. V., Makriyannis, A., & Salamone, J. D. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.002 · Cited by 89
Behavioral sensitization to heroin by cannabinoid pretreatment in the rat
Pontieri, F. E., Monnazzi, P., Scontrini, A., Buttarelli, F. R., & Patacchioli, F. R. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01056-1 · Cited by 85
Precipitated cannabinoid withdrawal is reversed by Δ9-tetrahydrocannabinol or clonidine
Lichtman, A. H., Fisher, J., & Martin, B. R. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00514-7 · Cited by 85
Marijuana use among adolescents
Gruber, A. J., & Pope, H. G. (2002) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(01)00011-6 · Cited by 90
Prevention of Cannabinoid Withdrawal Syndrome by Lithium: Involvement of Oxytocinergic Neuronal Activation
Cui, S.-S., Bowen, R. C., Gu, G.-B., Hannesson, D. K., Yu, P. H., & Zhang, X. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09867.2001 · Cited by 84
Chapter 5 The Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs
Gaetani, S., Dipasquale, P., Romano, A., Righetti, L., Cassano, T., Piomelli, D., & Cuomo, V. (2009) · International Review of Neurobiology · doi:10.1016/s0074-7742(09)85005-8 · Cited by 83
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice
Naderi, N., Haghparast, A., Saber-Tehrani, A. S., Rezaii, N., Alizadeh, A.-M., Khani, A., & Motamedi, F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.11.001 · Cited by 87
Role of Endocannabinoid Signaling in Anxiety and Depression
Patel, S., & Hillard, C. J. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_14 · Cited by 91
Ethanol, Endocannabinoids, and the Cannabinoidergic Signaling System
Hungund, B. L., Basavarajappa, B. S., Vadász, C., Kunos, G., de Fonseca, F. R., Colombo, G., Serra, S., Parsons, L. H., & Koob, G. F. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02575.x · Cited by 84
Self-citation
Differential Effects of Single Versus Repeated Alcohol Withdrawal on the Expression of Endocannabinoid System‐Related Genes in the Rat Amygdala
Serrano, A., Rivera, P., Pavón, F. J., Decara, J. M., Suárez, J., de Fonseca, F. R., & Parsons, L. H. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01686.x · Cited by 86
Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251
Vinklerová, J., Nováková, J., & Šulcová, A. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600204 · Cited by 82
CRF–CRF1 Receptor System in the Central and Basolateral Nuclei of the Amygdala Differentially Mediates Excessive Eating of Palatable Food
Iemolo, A., Blasio, A., Cyr, S. A. S., Jiang, F., Rice, K. C., Sabino, V., & Cottone, P. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.147 · Cited by 86
ROLE OF DORSAL HIPPOCAMPAL CANNABINOID RECEPTORS AND NITRIC OXIDE IN ANXIETY LIKE BEHAVIOURS IN RATS USING THE ELEVATED PLUS‐MAZE TEST
Roohbakhsh, A., Moghaddam, A. H., Massoudi, R., & Zarrindast, M. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04576.x · Cited by 82
Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain
Davis, M. P. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.1.85 · Cited by 82
Does amygdaloid corticotropin‐releasing hormone (CRH) mediate anxiety‐like behaviors? Dissociation of anxiogenic effects and CRH release
Merali, Z., Khan, S. A., Michaud, D. S., Shippy, S. A., & Anisman, H. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03468.x · Cited by 82
Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition
Cippitelli, A., Astarita, G., Duranti, A., Caprioli, G., Ubaldi, M., Stopponi, S., Kallupi, M., Sagratini, G., de Fonseca, F. R., Piomelli, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028142 · Cited by 81
Substance use modulates stress reactivity: Behavioral and physiological outcomes
Fosnocht, A. Q., & Briand, L. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.024 · Cited by 80
Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocorticolimbic areas via reduced dopamine D2 function
Alonso, R., Voutsinos‐Porche, B., Fournier, M., Labie, C., Steinberg, R., Souilhac, J., Fur, G. L., & Soubrié, P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00675-7 · Cited by 80
Increasing treatment options for cannabis dependence: A review of potential pharmacotherapies
Hart, C. L. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.03.027 · Cited by 77
The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain
Arnold, J. C., Topple, A. N., Mallet, P. E., Hunt, G. E., & McGregor, I. S. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03127-4 · Cited by 77

Authors: Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F.
Affiliations: F. Rodrı́guez de Fonseca and M. Navarro, Instituto Complutense de Drogodependencias, Departamento de Psicobiologı́a, Facultad de Psicologı́a, Universidad Complutense de Madrid, 28223 Madrid, Spain.
Universidad Complutense de Madrid (ES)
Corresponding author: Navarro, Miguel
ORCID: Navarro, Miguel
Koob, George F.
Weiss, Friedbert
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-06-27
Volume: 276
Issue: 5321
Pages: 2050-2054
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.276.5321.2050
OpenAlex: W2124997151
Cited by: 499
References: 45
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 11 · 2018: 19 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 21
FWCI: 27.34
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r03da008426-02)
National Institute on Drug Abuse (DA 08426)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: corticotropin-releasing factor, cannabinoid withdrawal, HU-210, SR141716A, Fos activation, central amygdala, limbic system, neural adaptation, drug addiction, stress response
MeSH terms: Rimonabant, Amygdala, Animals, Anxiety, Behavior, Animal, Brain, Corticosterone, Corticotropin-Releasing Hormone, Male, Piperidines, Pyrazoles, Receptors, Drug, Substance Withdrawal Syndrome, Dronabinol, Proto-Oncogene Proteins c-fos, Rats, Wistar, Microdialysis, Receptors, Cannabinoid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks