Cited by 608Reproductive Physiology in LivestockReproductive System and PregnancyHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

Sugimoto, Yukihiko, Yamasaki, Atsushi, Segi, Eri, Tsuboi, Kazuhito, Aze, Yoshiya, Nishimura, Tatsuya, Oida, Hiroji, Yoshida, Nobuaki, Tanaka, Takashi, Katsuyama, Masato, Hasumoto, Ken-yuh, Murata, Takahiko, Hirata, Masakazu, Ushikubi, Fumitaka, Negishi, Manabu, Ichikawa, Atsushi, Narumiya, Shuh·1997·Science

DOI 10.1126/science.277.5326.681

Open this paper in CoChat — free account

Abstract

Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F 2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.

Integrity signals

Registry

Crossref · 10.1126/science.277.5326.681

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., JAFFEE, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., et al. (1995) · Nature · doi:10.1038/378406a0 · Cited by 967
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Structure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631
Endocrine control of parturition
Thorburn, G. D., & Challis, J. R. G. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.863 · Cited by 426
Oxytocin Receptors: Triggers for Parturition and Lactation?
Soloff, M. S., Alexandrová, M., & Fernström, M. J. (1979) · Science · doi:10.1126/science.221972 · Cited by 394
Prostaglandin F2α identified as a Luteolytic Hormone in Sheep
McCracken, J. A., Carlson, J. C., Glew, M. E., GODING, J. R., Baird, D. T., GREEN, K., & Samuelsson, B. O. (1972) · Nature New Biology · doi:10.1038/newbio238129a0 · Cited by 384
Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha
HORTON, E. W., & Poyser, N. L. (1976) · Physiological Reviews · doi:10.1152/physrev.1976.56.4.595 · Cited by 345
Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
Young III, W. S., Shepard, E., Amico, J., Hennighausen, L., Wagner, K., LaMarca, M. E., McKinney, C., & Ginns, E. I. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05266.x · Cited by 308
INFLUENCE OF ACETYLSALICYLIC ACID, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE DURATION OF HUMAN GESTATION AND LABOUR
Lewis, R., & Schulman, J. (1973) · The Lancet · doi:10.1016/s0140-6736(73)92934-6 · Cited by 273
Correlation between Oxytocin Receptor Concentration and Responsiveness to Oxytocin in Pregnant Rat Myometrium: Effects of Ovarian Steroids*
Fuchs, A., Periyasamy, S., Alexandrová, M., & Soloff, M. S. (1983) · Endocrinology · doi:10.1210/endo-113-2-742 · Cited by 248

Show all 16 references

Research works printed but not linked: 2

S. Moncada R. J. Flower J. R. Vane in The Pharmacological Basis of Therapeutics A. G. Gilman L. S. Goodman T. W. Rall F. Murad Eds. (McGraw-Hill New York ed. 7 1985) pp. 660–673.
M. S. Soloff in The Onset of Labor: Cellular and Integrative Mechanisms D. McNellis J. Challis P. MacDonald P. Nathanielsz J. Roberts Eds. (Perinatology Press Ithaca NY 1988) pp. 87–123.

Sorted by citations

Items 301–400 of 608

RUNX2 co‐operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
Zhang, Q., Zuo, H., Yu, S., Lin, Y., Chen, S., Liu, H., & Chen, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29704 · Cited by 25
“mice are unable to deliver normal foetuses at term (Sugimoto et al., 1997) and Cd200‐knockout mice have an increased susceptibility to experimentally induced arthritis (Hoek, 2000).”
Background
Expression of PGF2alpha receptor mRNA in normal, hyperplastic and neoplastic skin
Müller, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.1063 · Cited by 25
Involvement of endothelin‐1 and its receptors in PGF2α‐induced luteolysis in the rat
Girsh, E., & Dekel, N. (2002) · Molecular Reproduction and Development · doi:10.1002/mrd.10159 · Cited by 25
“The fact that PGF2a is dispensable in cycling rodents was manifested in the PGF2a receptor knockout animal model (Sugimoto et al., 1997).”
Background
Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts
Taketomi, Y., Higashi, T., Kano, K., Miki, Y., Mochizuki, C., Toyoshima, S., Okayama, Y., Nishito, Y., Nakae, S., Tanaka, S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.012 · Cited by 26
Cyclic AMP‐mediated chloride secretion is induced by prostaglandin F2αin human isolated colon
Collins, D., Hogan, A. M., Mm, S., Baird, A. W., & Winter, D. C. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00464.x · Cited by 24
Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle
Huang, N., Liu, B., Dong, Z.-H., Mao, W., Zhang, N., Li, C., & Cao, J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.08.002 · Cited by 24
Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17β-estradiol regulated mRNA transcriptome of the rat uterus
Helle, J., Keiler, A. M., Zierau, O., Dörfelt, P., Vollmer, G., Lehmann, L., Chittur, S. V., Tenniswood, M., Welsh, J., & Kretzschmar, G. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.004 · Cited by 24
Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells
Fujino, T., Yuhki, K., Yamada, T., Hara, A., Takahata, O., Okada, Y., Xiao, C., Ma, H., Karibe, H., Iwashima, Y., et al. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704749 · Cited by 24
Self-citation
PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells
Chandras, C., Harris, T. E., Bernal, A. L., Abayasekara, D. R. E., & Michael, A. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0128 · Cited by 25
“Since PTGFR receptors are known to inhibit (rather than stimulate) progesterone production (Sugimoto et al. 1997, Tsai et al. 1998, 2001), it seems highly unlikely that the steroidogenic response to PGE2 (even at concentrations O 30 nM) is mediated via the PTGFR receptor.”
Background
Maturation of Spontaneous and Agonist-Induced Uterine Contractions in the Peripartum Mouse Uterus1
Mackler, A. M., Ducsay, C. A., Veldhuis, J. D., & Yellon, S. M. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.4.873 · Cited by 24
Differential COX localization and PG release in Thy-1+ and Thy-1− human female reproductive tract fibroblasts
Koumas, L., & Phipps, R. P. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2002 · Cited by 24
“COX-2 expression is suggested to be responsible for induction of PGF2 (33), which is a vasoconstrictor and responsible for labor induction in mice (42).”
Background
Prostaglandin F2α (PGF2α) and Prolactin Signaling: PGF2α-Mediated Inhibition of Prolactin Receptor Expression in the Corpus Luteum
Stocco, C. O., Djiane, J., & Gibori, G. (2003) · Endocrinology · doi:10.1210/en.2003-0420 · Cited by 24
“On the other hand, mice rendered deficient for the PGF2 -R gene do not show the normal prepartum drop in progesterone and consequently do not give birth (2).”
BackgroundMethod
Genomic Structure, 5′ Flanking Sequences, and Precise Localization in 1P31.1 of the Human Prostaglandin F Receptor Gene
Betz, R. C., Lagercrantz, J., Kedra, D., Dumanski, J. P., & Nordenskjöld, A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9827 · Cited by 24
Druggable Prostanoid Pathway
Mazaleuskaya, L. L., & Ricciotti, E. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50621-6_3 · Cited by 23
Expression of cyclooxygenase genes and production of prostaglandins during ovulation in the ovarian follicles of Xenopus laevis
Sena, J. A., & Liu, Z. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.04.012 · Cited by 23
Role of Aldo–Keto Reductase Enzymes in Mediating the Timing of Parturition
Byrns, M. C. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00092 · Cited by 24
“The principle phenotype of FP receptor knockout mice is the inability to deliver young at term, which is rescued by the administration of oxytocin (Sugimoto et al., 1997; Kawamata et al., 2008).”
Background
Gene knockouts that cause female infertility: search for novel contraceptive targets
Rajesh, C. (2005) · Frontiers in bioscience · doi:10.2741/1709 · Cited by 23
Role of Vascular Endothelial Growth Factor in Maintenance of Pregnancy in Mice
Wada, Y., Ozaki, H., Abe, N., Mori, A., Sakamoto, K., Nagamitsu, T., Nakahara, T., & Ishii, K. (2013) · Endocrinology · doi:10.1210/en.2012-1967 · Cited by 22
Activation of Gq/11 in the Mouse Corpus Luteum Is Required for Parturition
Mejia, R. B., Waite, C., & Ascoli, M. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1324 · Cited by 22
“Deletion of G q/11 in mouse granulosa cells impairs parturition, the increase in luteal Akr1c18 expression, and the drop in progesterone that occurs at the end of pregnancy Because the luteolytic actions of PGF2 are essential for parturition (22, 24, 39), we next examined several additional aspects of this process in…”
Background
Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells
Kim, S. O., Markosyan, N., Pepe, G. J., & Duffy, D. M. (2015) · Reproduction · doi:10.1530/rep-14-0412 · Cited by 22
“1988), disruption of PTGFR expression in mice did not prevent ovulation (Sugimoto et al. 1997).”
Background
Suppression of Protein Kinase C Signaling by the Novel Isoform for Bovine PGF2α Receptor
Ishii, Y., & Sakamoto, K. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5106 · Cited by 22
A model and simulation of uterine contractions
Cochran, A. L., & Gao, Y. (2013) · Mathematics and Mechanics of Solids · doi:10.1177/1081286513507940 · Cited by 21
“For example, the endocrinology of human parturition is believed to involve multiple parallel sequences of events [12, 71–73], unlike rat parturition which can be inhibited by targeting the receptor for the specific prostaglandin known as PGF2α [74].”
Background
15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth
Rinaldi, S. F., Catalano, R. D., Wade, J., Rossi, A. G., & Norman, J. E. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gau117 · Cited by 21
“role for elevated Ptgs2 expression, and subsequent production of prostaglandins such as PGF2a and PGE2 in the onset of parturition in mice (Sugimoto et al., 1997; Gross et al., 1998, 2000; Tsuboi et al., 2003).”
Background
Mammalian G-protein function in vivo: New insights through altered gene expression
Offermanns, S. (2006) · Springer eBooks · doi:10.1007/bfb0035551 · Cited by 21
Reactive oxygen and nitrogen species: multifaceted regulators of ovarian activity
Bezdíček, J., Sekaninová, J., Janků, M., Makarevič, A., Luhová, L., Dujíčková, L., & Petřivalský, M. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf032 · Cited by 22
“However, they were unable to luteolyze CL and subsequently initiate birth at term [166].”
Genetic evidence of multiple loci in dystocia - difficult labour
Algovik, M., Kivinen, K., Peterson, H. V., Westgren, M., & Kere, J. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-105 · Cited by 20
“Animal studies have shown that knock-out mice models of genes regulating parturition exhibit dystocia [9,10], but this has not yet been shown in humans [11].”
Background
Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm
Unlugedik, E., Alfaidy, N., Holloway, A. C., Lye, S. J., Bocking, A. D., Challis, J. R. G., & Gibb, W. (2010) · Reproduction Fertility and Development · doi:10.1071/rd09148 · Cited by 20
“…that changes in the relative expression of relaxant or contractile PG © CSIRO 2010 10.1071/RD09148 1031-3613/10/050796 receptors may participate in both maintenance of uterine quiescence for the majority of gestation and the switch to contractions at the time of delivery (Sugimoto et al. 1997).”
BackgroundInfluential
The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes
Guan, P.-P., Ding, W.-Y., & Wang, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0029-2 · Cited by 20
Prostanoids In Health and Disease; Lessons From Receptor-Knockout Mice
Kobayashi, T., & Narumiya, S. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0193-0_90 · Cited by 20
Self-citation
Functional evidence for divergent receptor activation mechanisms of luteotrophic and luteolytic events in the human corpus luteum
Ottander, U. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.5.391 · Cited by 20
Structure, Function, and Regulation of the Corpus Luteum
Stouffer, R. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50017-8 · Cited by 20
The Role(s) of Eicosanoids and Exosomes in Human Parturition
Mosaad, E. M. O., Peiris, H. N., Holland, O. J., Garcia, I. M., & Mitchell, M. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.594313 · Cited by 21
“…in reproductive physiology are extensively studied in seminal fluid (Samuelsson, 1963; Alexandre et al., 2007; Remes Lenicov et al., 2012; Szczykutowicz et al., 2019), luteolytic actions (Vijayakumar and Walters, 1983; Bennegård et al., 1991; Miceli et al., 2001) and uterine physiology…”
Background
Prostaglandin F2α regulation and function during ovulation and luteinization in cows
de Moraes, F. P., D’Ávila, C. A., de Oliveira, F. C., de Castro, N. Á., Vieira, A. D., Schneider, A., Pfeifer, L. F. M., Pegoraro, L. M. C., Ferreira, R., Ferst, J. G., et al. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.05.008 · Cited by 19
Progesterone withdrawal and parturition
Mesiano, S. A. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106177 · Cited by 19
Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction
Inagaki, M., Nishimura, T., Nakanishi, T., Shimada, H., Noguchi, S., Akanuma, S., Tachikawa, M., Hosoya, K., Tamai, I., Nakashima, E., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101098 · Cited by 20
Self-citation
Involvement of prostaglandin F2α receptor in ATP-induced mechanical allodynia
Kunori, S., Matsumura, S., Mabuchi, T., Tatsumi, S., Sugimoto, Y., Minami, T., & Ito, S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.069 · Cited by 19
Self-citation
Luteal phospholipase A2 activity increases during functional and structural luteolysis in pregnant rats
Kurusu, S., Kaizo, K., Ibashi, M., Kawaminami, M., & Hashimoto, I. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00389-0 · Cited by 19
Uteroglobin Inhibits Prostaglandin F2α Receptor-mediated Expression of Genes Critical for the Production of Pro-inflammatory Lipid Mediators
Mandal, A. K., Ray, R., Zhang, Z., Chowdhury, B., Pattabiraman, N., & Mukherjee, A. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502375200 · Cited by 19
Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium
Ilicic, M., Zakár, T., & Paúl, J. (2017) · BioMed Research International · doi:10.1155/2017/4589214 · Cited by 19
Dietary omega-3 fatty acids differentially influence ova release and ovarian cyclooxygenase-1 and cyclooxygenase-2 expression in rats
Broughton, K. S., Rule, D. C., Ye, Y., Zhang, X., Driscoll, M., & Culver, B. W. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.01.007 · Cited by 19
“Mice lacking a PGF2α receptor do not show ovulatory defects [51], indicating that PGE2 is the primary controller of ovulation.”
Background
An EP4 Receptor Agonist Prevents Indomethacin-Induced Closure of Rat Ductus Arteriosus In Vivo
Kajino, H., Taniguchi, T., Fujieda, K., Ushikubi, F., & Muramatsu, I. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000139409.25014.35 · Cited by 19
“In the mother, PG are key players in the initiation and progression of parturition (1,2), whereas in the fetus they participate in the regulation of circulatory change at birth.”
BackgroundSelf-citation
Coupling between cyclooxygenases and prostaglandin F2α synthase
Nakashima, K., Ueno, N., Kamei, D., Tanioka, T., Nakatani, Y., Murakami, M., & Kudo, I. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00092-1 · Cited by 19
Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility
Herington, J. L., O’Brien, C., Robuck, M. F., Lei, W., Brown, N., Slaughter, J. C., Paria, B. C., Mahadevan-Jansen, A., & Reese, J. (2018) · Endocrinology · doi:10.1210/en.2017-00647 · Cited by 18
“On postpartum day 1, the transcript levels of Ptgs2 and Ptgfr remained significantly greater in Cox-1KO mice compared with time-matched WT mice (P = 0.0003 and P , 0.0001, respectively).”
Influential
Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction
Strauss, J. F., & FitzGerald, G. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00004-4 · Cited by 21
Oxytocin-induced phasic and tonic contractions are modulated by the contractile machinery rather than the quantity of oxytocin receptor
Kawamata, M., Tonomura, Y., Kimura, T., Sugimoto, Y., Yanagisawa, T., & Nishimori, K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00492.2006 · Cited by 18
“(46) reported that FP KO mice failed to labor, and the expression levels of otr did not increase in uteri even at 20.”
BackgroundSelf-citation
Blood-aqueous barrier in prostaglandin EP2 receptor knockout mice
Bhattacherjee, P., Mukhopadhyay, P., Tilley, S. L., Koller, B. H., Geoghgan, T., & Paterson, C. A. (2002) · Ocular Immunology and Inflammation · doi:10.1076/ocii.10.3.187.15601 · Cited by 18
Physiological Positive Feedback Mechanisms
Abdel-Sater, K. A. (2011) · American Journal of Biomedical Sciences · doi:10.5099/aj110200145 · Cited by 18
Family 1 G protein-coupled receptor function in the CNS Insights from gene knockout mice
Karasinska, J. M. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00221-7 · Cited by 18
Complementary Mechanisms of Enhanced Oxytocin-Stimulated Prostaglandin E2Synthesis in Rabbit Amnion at the End of Gestation1
Jeng, Y., Liebenthal, D. A., Straková, Z., Ives, K. L., Hellmich, M. R., & Soloff, M. S. (2000) · Endocrinology · doi:10.1210/endo.141.11.7761 · Cited by 18
Progesterone control of myometrial contractility
Shynlova, O. P., Nadeem, L., & Lye, S. J. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106397 · Cited by 17
The complete control of murine pregnancy from embryo implantation to parturition
Terakawa, J., Watanabe, T., Obara, R., Sugiyama, M., Inoue, N., Ohmori, Y., Hosaka, Y. Z., & Hondo, E. (2011) · Reproduction · doi:10.1530/rep-11-0288 · Cited by 17
“Mice deficient in the prostaglandin receptor that binds to prostaglandin F2a cannot deliver their fetuses because the corpora lutea does not regress, and progesterone levels remain high (Sugimoto et al. 1997).”
Background
Parturition failure in mice lacking Mamld1
Miyado, M., Miyado, K., Katsumi, M., Saito, K., Nakamura, A., Shihara, D., Ogata, T., & Fukami, M. (2015) · Scientific Reports · doi:10.1038/srep14705 · Cited by 17
“It has been shown that administration of low-dose oxytocin results in persistent progesterone production and subsequent parturition failure, whereas high-dose oxytocin causes uterine contraction and early labour 12 .”
Influential
Prostaglandin Biosynthesis and Action in the Ovary
Sirois, J., Boerboom, D., & Sayasith, K. (2004) · Elsevier eBooks · doi:10.1016/b978-012444562-8/50014-8 · Cited by 17
Effect of Oxytocin Receptor Blockade on Rat Myometrial Responsiveness to Prostaglandin F2α1
Engstrøm, T., Bratholm, P. S., Christensen, N. J., & Vilhardt, H. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.5.1443 · Cited by 17
“In both cases, however, a reduction in serum progesterone induced by ovariectomy [1] or the administration of a progesterone receptor antagonist [2] secured normal delivery.”
Background
Induction of Oxytocin Receptor Gene Expression in Rabbit Amnion Cells
Jeng, Y., Lolait, S. J., & Soloff, M. S. (1998) · Endocrinology · doi:10.1210/en.139.8.3449 · Cited by 17
Genetic Analysis of Fetal Development and Parturition Control in the Mouse
Muglia, L. J. (2000) · Pediatric Research · doi:10.1203/00006450-200004000-00005 · Cited by 17
Exacerbation of Intracranial Aneurysm and Aortic Dissection in Hypertensive Rat Treated With the Prostaglandin F–Receptor Antagonist AS604872
Fukuda, M., Aoki, T., Manabe, T., Maekawa, A., Shirakawa, T., Kataoka, H., Takagi, Y., Miyamoto, S., & Narumiya, S. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14148fp · Cited by 16
Self-citation
Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy
Li, X., Ballantyne, L. L., Crawford, M. C., FitzGerald, G. A., & Funk, C. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-30636-x · Cited by 16
Pharmacokinetics and anti‐inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses
Knych, H. K. D., Arthur, R. M., McKemie, D. S., Baden, R. W., Seminoff, K., & Kass, P. H. (2020) · Equine Veterinary Journal · doi:10.1111/evj.13260 · Cited by 16
Prostaglandin E Receptor EP1 Subtype but Not Prostacyclin IP Receptor Involved in Mucosal Blood Flow Response of Mouse Stomachs following Barrier Disruption
Komoike, Y., Nakashima, M., Nakagiri, A., & Takeuchi, K. (2003) · Digestion · doi:10.1159/000072057 · Cited by 16
“However, there have been only a few studies dealing with the role of endogenous PGI 2 in the housekeeping action in the stomach.Recently, an animal model lacking various receptors for prostanoids has been established [”
Background
F2-isoprostane induced prostaglandin formation in the rabbit
Basu, S. (2006) · Free Radical Research · doi:10.1080/10715760500511492 · Cited by 16
Bisphenol A, Dichlorodiphenyltrichloroethane (DDT) and Vinclozolin Affect ex-vivo Uterine Contraction in Rats via Uterotonin (Prostaglandin F2α, Acetylcholine and Oxytocin) Related Pathways
Salleh, N., Giribabu, N., Feng, A. O. M., & Myint, K. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.11957 · Cited by 16
“prostaglandin F (FP)[20], muscarinic and oxytocic receptors respectively [21].”
Background
TP and/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F 2α in mice and/or humans
Liu, B., Li, J., Yan, H., Tian, D., Li, H., Zhang, Y., Guo, T., Wu, X., Luo, W., & Zhou, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201801064rr · Cited by 16
“FP mediates PGF2a-evoked uterine smooth muscle contraction (4, 8).”
Background
Immunocytochemical localization of lung-type prostaglandin F synthase in the rat spinal cord
Suzuki-Yamamoto, T., Toida, K., Tsuruo, Y., Watanabe, K., & Ishimura, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02709-8 · Cited by 16
Molecular Events Defining Follicular Developments and Steroidogenesis in the Ovary
Orly, J. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-221-0_12 · Cited by 16
Preterm labour
Bernal, A. L., & TambyRaja, R. L. (2000) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1053/beog.1999.0068 · Cited by 16
Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish
Kwok, A. H. Y., Wang, Y., & Leung, F. C.-C. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.05.002 · Cited by 14
Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene,Ddr2,as a regulator of ovarian function
Matsumura, H., Kanô, K., de Evsikova, C. M., Young, J. A., Nishina, P. M., Naggert, J. Κ., & Naito, K. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00073.2009 · Cited by 15
The telomere gestational clock: increasing short telomeres at term in the mouse
Phillippe, M., Sawyer, M. R., & Edelson, P. K. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.01.218 · Cited by 15
Inhibition of Prostaglandin F2α Receptors Exaggerates HCl-Induced Lung Inflammation in Mice
Maehara, T., & Fujimori, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312843 · Cited by 15
“AL8810 (10 mg/kg in 1% DMSO, Cayman Chemical, Ann Arbor, MI, USA) was administered intraperitoneally at 1 h before HCl administration.”
MethodInfluential
ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function
Naik, J., de Waart, D. R., Utsunomiya, K. S., Duijst, S., Mok, K. S., Elferink, R. P. J. O., Bosma, P. J., & Paulusma, C. C. (2015) · Digestive Diseases · doi:10.1159/000371665 · Cited by 15
Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus
Oba, K., Hosono, K., Amano, H., Okizaki, S.-I., Ito, Y., Shichiri, M., & Majima, M. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.10.022 · Cited by 15
Possible Involvement of p38 Mitogen-Activated Protein Kinase in Decidual Function in Parturition
Takanami-Ohnishi, Y., Asada, S., Tsunoda, H., Fukamizu, A., Goto, K., Yoshikawa, H., Kubo, T., SUDO, T., Kimura, S., & Kasuya, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5895 · Cited by 15
Preterm labour: association between labour physiology, tocolysis and prevention
Illanes, S. E., Pérez‐Sepúlveda, A., Rice, G. E., & Mitchell, M. D. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.905541 · Cited by 15
“In an experimental setting, PGF2a receptor knockout mice do not respond to OT during pregnancy nor does OT receptor expression increase in association with labour [66].”
Background
Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice
Kashiwagi, H., Yuhki, K., Imamichi, Y., Kojima, F., Kumei, S., Tasaki, Y., Narumiya, S., & Ushikubi, F. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1688906 · Cited by 15
Self-citation
The dual face of parathyroid hormone and prostaglandins in the osteoimmune system
Agas, D., Marchetti, L., Capitani, M., & Sabbieti, M. G. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00290.2013 · Cited by 16
Tocolytic effect of a selective FP receptor antagonist in rodent models reveals an innovative approach to the treatment of preterm labor
Chollet, A., Tos, E. G., & Cirillo, R. (2007) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-7-s1-s16 · Cited by 15
“It was known that FP-deficient mice showed impaired parturition by lack of luteolysis and consequently absence of progesterone withdrawal, a necessary event to trigger labor in most animal species [25].”
Background
Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F 2α receptor
Boukanoun, M. K., Hou, X., Nikolajev, L., Ratni, S., Olson, D. M., Claing, A., Laporte, S. A., Chemtob, S., & Lubell, W. D. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00962f · Cited by 14
Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery – the influence of external oxytocin
Liedman, R., Hansson, S. R., Igidbashian, S., & Åkerlund, M. (2009) · Gynecological Endocrinology · doi:10.1080/09513590802573213 · Cited by 14
“Ovariectomy, leading to a needed progesterone withdrawal, restored the induction of oxytocin receptors and permitted successful delivery in the PGF receptor-deficient mice [27].”
BackgroundInfluential
Gastric mucosal protection against ethanol by EP2and EP4signaling through the inhibition of leukotriene C4production
Hattori, Y., Ohno, T., Ae, T., Saeki, T., Arai, K., Mizuguchi, S., Saigenji, K., & Majima, M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00292.2007 · Cited by 14
“Genes for each of these receptors have been disrupted and the corresponding knockout mice have been produced (1, 19, 22, 25, 26, 28, 40, 45).”
Background
Lipid Classes, Fatty Acid Composition, and Glycerolipid Molecular Species of the Red Alga Gracilaria vermiculophylla, a Prostaglandin-Producing Seaweed
Honda, M., Ishimaru, T., & Itabashi, Y. (2016) · Journal of Oleo Science · doi:10.5650/jos.ess16026 · Cited by 14
“Prostaglandins are important compounds that are widely used in the pharmaceutical field because they inhibit platelet aggregation 9 ） , and have oxytocic 10 ） and gastric antise-cretory actions 11 ） .”
Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension
Yamagishi-Kimura, R., Honjo, M., & Aihara, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-29273-1 · Cited by 14
Leishmania braziliensis prostaglandin F2α synthase impacts host infection
Alves‐Ferreira, E. V. C., Ferreira, T. R., Walrad, P. B., Kaye, P. M., & Cruz, Â. K. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-3883-z · Cited by 14
“In mammals, PGF 2α is mostly related to ovulation, luteolysis, uterine contraction and the onset of labor [7] .”
Background
Topographical specialization of prostaglandin function in late pregnancy and at parturition in the baboon
Nathanielsz, P. W., Smith, G. C. S., & Wu, W. X. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.04.008 · Cited by 14
Labour is associated with decreased expression of the PGF2 receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua
Hay, A., Wood, S. L., Olson, D. M., & Slater, D. M. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq046 · Cited by 14
“pregnant past term (Sugimoto et al., 1997), and administration of THG113, a PTGFR antagonist, can delay preterm birth in both mice”
Background
Prostaglandin F2αReceptor-Dependent Regulation of Prostaglandin Transport
Vezza, R., Rokach, J., & FitzGerald, G. A. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.6.1506 · Cited by 14
The Roles Played by FP/EP3 Receptors During Pressure-lowering in Mouse Eyes Mediated by a Dual FP/EP3 Receptor Agonist
Yamagishi-Kimura, R., Honjo, M., & Aihara, M. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.2.24 · Cited by 13
Roles of lipid mediators in early pregnancy events
Aikawa, S., & Hirota, Y. (2024) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12597 · Cited by 13
“34,38 Although previous reports demonstrate the significant correlation of PG receptors with ovulation, fertilization, and parturition, 39–41 the receptor playing key roles in peri-implantation processes remains unidentified.”
Background
Identification of a myometrial molecular profile for dystocic labor
Brennan, D. J., McGee, S. F., Rexhepaj, E., O’Connor, D. P., Robson, M. S., & O’Herlihy, C. (2011) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-11-74 · Cited by 14
“Additionally, transgenic knockout mouse models examining prostaglandin F2a receptor [11] and testosterone 5-a-reductase type 1 [12], respectively, exhibit an absence of parturition, although screening for mutations in these candidate dystocia-related genes in humans proved unsuccessful [13].”
Out of step societal and Darwinian adaptation during evolution is the cause of multiple women’s health issues
Pei, Z., Lu, W., Feng, Y., Xu, C., & Hsueh, A. J. W. (2022) · Human Reproduction · doi:10.1093/humrep/deac156 · Cited by 15
Reduction of aquaporin‐8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2α receptor
Shioji, M., Fukuda, H., Kanzaki, T., Wasada, K., Kanagawa, T., Shimoya, K., Mu, J., Sugimoto, Y., & Murata, Y. (2006) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2006.00425.x · Cited by 13
Self-citation
Involvement of hypoxia and inflammation in early pregnancy loss mediated by Shiga toxin type 2
Sacerdoti, F., Amaral, M. M., Aisemberg, J., Cymeryng, C. B., Franchi, A. M., & Ibarra, C. (2015) · Placenta · doi:10.1016/j.placenta.2015.03.005 · Cited by 13
“, prostaglandin-induced luteolysis [35] or a secondary outcome related to a failing pregnancy is not known, but our results seem to support the conclusion that toxin exposure activate different pathways to miscarriage and P4 withdrawal could be a consequence of them.”
Progesterone Receptor Expression Declines in the Guinea Pig Uterus during Functional Progesterone Withdrawal and in Response to Prostaglandins
Welsh, T. N., Hirst, J. J., Palliser, H. K., & Zakár, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105253 · Cited by 13
“with the consequent decline of maternal plasma progesterone levels followed by the increase of OTR and other contractionassociated protein expression in the myometrium [22].”
ORIGINAL ARTICLE: Calcineurin/NFAT Pathway: A Novel Regulator of Parturition
Tabata, C., Ogita, K., Sato, K., Nakamura, H., Qing, Z., Negoro, H., Kumasawa, K., Temma‐Asano, K., Tsutsui, T., Nishimori, K., et al. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00710.x · Cited by 13
Elevated utero/placental GR/NR3C1 is not required for the induction of parturition in the dog
Gram, A., Trachsel, A., Boos, A., & Kowalewski, M. P. (2016) · Reproduction · doi:10.1530/rep-16-0213 · Cited by 13
Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels†
Sun, X., Tavenier, A., Deng, W., Leishman, E., Bradshaw, H. B., & Dey, S. K. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox164 · Cited by 13
“Prostaglandins are major players in determining the strength and frequency of myometrial contractions [60, 61].”
Background
Control of Ovarian Function
Elvin, J. A., & Matzuk, M. M. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-102-2_4 · Cited by 13
Characterization and functional analysis of the 5′-flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene
Hirabayashi, K., Ishida, M., Suzuki, M., Yamanouchi, K., & Nishihara, M. (2004) · Biochemical Journal · doi:10.1042/bj20040276 · Cited by 13
Mutant mouse models and their contribution to our knowledge of corpus luteum development, function and regression
Henkes, L. E., Davis, J. S., & Rueda, B. R. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-87 · Cited by 13
Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse
Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13

Authors: Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-Y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., & Narumiya, S.
Affiliations: Kyoto University (JP)
Y. Sugimoto, A. Yamasaki, E. Segi, K. Tsuboi, M. Katsuyama, K. Hasumoto, M. Negishi, A. Ichikawa, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
Corresponding author: Ichikawa, Atsushi
ORCID: Sugimoto, Yukihiko
Yamasaki, Atsushi
Tsuboi, Kazuhito
Nishimura, Tatsuya
Yoshida, Nobuaki
Tanaka, Takashi
Katsuyama, Masato
Ichikawa, Atsushi
Narumiya, Shuh
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-08
Volume: 277
Issue: 5326
Pages: 681-683
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.277.5326.681
OpenAlex: W2142980049
Cited by: 608
References: 16
Citations by year: 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 11
FWCI: 85.53
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: childbirth, prostaglandin F2alpha, FP receptor, oxytocin receptor, luteolysis, progesterone, ovariectomy, luteal cells, pregnancy, knockout mice, estrous cycle
MeSH terms: Animals, Corpus Luteum, Female, Heterozygote, Homozygote, Labor, Obstetric, Male, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Pregnancy, Progesterone, Receptors, Prostaglandin, Uterine Contraction, Uterus, Dinoprost, Receptors, Oxytocin, Gene Targeting, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks