Cited by 608Reproductive Physiology in LivestockReproductive System and PregnancyHypothalamic control of reproductive hormones

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Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

Sugimoto, Yukihiko, Yamasaki, Atsushi, Segi, Eri, Tsuboi, Kazuhito, Aze, Yoshiya, Nishimura, Tatsuya, Oida, Hiroji, Yoshida, Nobuaki, Tanaka, Takashi, Katsuyama, Masato, Hasumoto, Ken-yuh, Murata, Takahiko, Hirata, Masakazu, Ushikubi, Fumitaka, Negishi, Manabu, Ichikawa, Atsushi, Narumiya, Shuh·1997·Science

DOI 10.1126/science.277.5326.681

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Abstract

Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F 2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.

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Background

Authors: Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-Y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., & Narumiya, S.
Affiliations: Kyoto University (JP)
Y. Sugimoto, A. Yamasaki, E. Segi, K. Tsuboi, M. Katsuyama, K. Hasumoto, M. Negishi, A. Ichikawa, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
Corresponding author: Ichikawa, Atsushi
ORCID: Sugimoto, Yukihiko
Yamasaki, Atsushi
Tsuboi, Kazuhito
Nishimura, Tatsuya
Yoshida, Nobuaki
Tanaka, Takashi
Katsuyama, Masato
Ichikawa, Atsushi
Narumiya, Shuh
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-08
Volume: 277
Issue: 5326
Pages: 681-683
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.277.5326.681
OpenAlex: W2142980049
Cited by: 608
References: 16
Citations by year: 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 11
FWCI: 85.53
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: childbirth, prostaglandin F2alpha, FP receptor, oxytocin receptor, luteolysis, progesterone, ovariectomy, luteal cells, pregnancy, knockout mice, estrous cycle
MeSH terms: Animals, Corpus Luteum, Female, Heterozygote, Homozygote, Labor, Obstetric, Male, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Pregnancy, Progesterone, Receptors, Prostaglandin, Uterine Contraction, Uterus, Dinoprost, Receptors, Oxytocin, Gene Targeting, Mice

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Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

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