The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Abstract
Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F 2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.
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“Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors56–59.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [58]
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Metadata
- Authors
- Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-Y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., & Narumiya, S.
- Affiliations
- Kyoto University (JP)
- Y. Sugimoto, A. Yamasaki, E. Segi, K. Tsuboi, M. Katsuyama, K. Hasumoto, M. Negishi, A. Ichikawa, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
- Corresponding author
- Ichikawa, Atsushi
- ORCID
- Venue
- Science
- Published
- 1997-08
- Volume
- 277
- Issue
- 5326
- Pages
- 681-683
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142980049
- Cited by
- 608
- References
- 16
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 11
- FWCI
- 85.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- childbirth, prostaglandin F2alpha, FP receptor, oxytocin receptor, luteolysis, progesterone, ovariectomy, luteal cells, pregnancy, knockout mice, estrous cycle
- MeSH terms
- Animals, Corpus Luteum, Female, Heterozygote, Homozygote, Labor, Obstetric, Male, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Pregnancy, Progesterone, Receptors, Prostaglandin, Uterine Contraction, Uterus, Dinoprost, Receptors, Oxytocin, Gene Targeting, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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